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The non-benzodiazepine anxiolytic etifoxine limits the sensory-affective expression of pain following streptozotocin-induced diabetic neuropathy

View ORCID ProfileGéraldine Gazzo, Marlene Salgado Ferrer, View ORCID ProfilePierrick Poisbeau
doi: https://doi.org/10.1101/2021.02.22.432248
Géraldine Gazzo
Centre National de la Recherche Scientifique, University of Strasbourg, Institute for Cellular and Integrative Neuroscience (INCI), 67000 Strasbourg, France
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Marlene Salgado Ferrer
Centre National de la Recherche Scientifique, University of Strasbourg, Institute for Cellular and Integrative Neuroscience (INCI), 67000 Strasbourg, France
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Pierrick Poisbeau
Centre National de la Recherche Scientifique, University of Strasbourg, Institute for Cellular and Integrative Neuroscience (INCI), 67000 Strasbourg, France
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  • For correspondence: poisbeau@inci-cnrs.unistra.fr
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Abstract

More than 450 million people worldwide suffer from diabetes, or 1 in 11 people. Chronic hyperglycemia degrades patients’ quality of life and the development of neuropathic pain contributes to the burden of this disease. In this study, we used the mouse model of streptozocin-induced diabetic type 1 neuropathy to assess the analgesic potential of etifoxine. Etifoxine is a prescribed anxiolytic that increases GABAAA receptor function through a direct positive allosteric modulation effect and, indirectly, by stimulating the production of endogenous GABAA receptor positive modulators such as allopregnanolone-type neurosteroids. We show that a curative or preventive treatment strongly and durably reduces mechanical hyperalgesia and anxiety in diabetic neuropathic mice. This analgesic and neuroprotective effect on painful symptoms and emotional comorbidities is promising and should now be clinically evaluated.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted February 22, 2021.
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The non-benzodiazepine anxiolytic etifoxine limits the sensory-affective expression of pain following streptozotocin-induced diabetic neuropathy
Géraldine Gazzo, Marlene Salgado Ferrer, Pierrick Poisbeau
bioRxiv 2021.02.22.432248; doi: https://doi.org/10.1101/2021.02.22.432248
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The non-benzodiazepine anxiolytic etifoxine limits the sensory-affective expression of pain following streptozotocin-induced diabetic neuropathy
Géraldine Gazzo, Marlene Salgado Ferrer, Pierrick Poisbeau
bioRxiv 2021.02.22.432248; doi: https://doi.org/10.1101/2021.02.22.432248

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