Resurrection of human endogenous retroviruses during aging reinforces senescence

Xiaoqian Liu; Zunpeng Liu; Liang Sun; Jie Ren; Zeming Wu; Xiaoyu Jiang; Qianzhao Ji; Qianran Wang; Yanling Fan; Yusheng Cai; Si Wang; Wei Li; Gang Cao; Moshi Song; Falong Lu; Weiqi Zhang; Jing Qu; Guang-Hui Liu

doi:10.1101/2021.02.22.432260

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Resurrection of human endogenous retroviruses during aging reinforces senescence

Xiaoqian Liu, Zunpeng Liu, Liang Sun, Jie Ren, Zeming Wu, Xiaoyu Jiang, Qianzhao Ji, Qianran Wang, Yanling Fan, Yusheng Cai, Si Wang, Wei Li, Gang Cao, Moshi Song, Falong Lu, Weiqi Zhang, Jing Qu, View ORCID ProfileGuang-Hui Liu

doi: https://doi.org/10.1101/2021.02.22.432260

Xiaoqian Liu

1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

7University of Chinese Academy of Sciences, Beijing 100049, China

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Zunpeng Liu

1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

7University of Chinese Academy of Sciences, Beijing 100049, China

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Liang Sun

9The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, China

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Jie Ren

4CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China

5China National Center for Bioinformation, Beijing 100101, China

6Institute for Stem cell and Regeneration, CAS, Beijing 100101, China

7University of Chinese Academy of Sciences, Beijing 100049, China

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Zeming Wu

1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

7University of Chinese Academy of Sciences, Beijing 100049, China

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Xiaoyu Jiang

2State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

7University of Chinese Academy of Sciences, Beijing 100049, China

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Qianzhao Ji

2State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

7University of Chinese Academy of Sciences, Beijing 100049, China

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Qianran Wang

3Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China

4CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China

7University of Chinese Academy of Sciences, Beijing 100049, China

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Yanling Fan

3Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China

4CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China

7University of Chinese Academy of Sciences, Beijing 100049, China

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Yusheng Cai

2State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

7University of Chinese Academy of Sciences, Beijing 100049, China

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Si Wang

2State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

6Institute for Stem cell and Regeneration, CAS, Beijing 100101, China

7University of Chinese Academy of Sciences, Beijing 100049, China

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Wei Li

3Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China

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Gang Cao

8State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070

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Moshi Song

2State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

6Institute for Stem cell and Regeneration, CAS, Beijing 100101, China

7University of Chinese Academy of Sciences, Beijing 100049, China

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Falong Lu

7University of Chinese Academy of Sciences, Beijing 100049, China

10State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China

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Weiqi Zhang

4CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China

5China National Center for Bioinformation, Beijing 100101, China

6Institute for Stem cell and Regeneration, CAS, Beijing 100101, China

7University of Chinese Academy of Sciences, Beijing 100049, China

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For correspondence: ghliu@ioz.ac.cn qujing@ioz.ac.cn zhangwq@big.ac.cn

Jing Qu

1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

6Institute for Stem cell and Regeneration, CAS, Beijing 100101, China

7University of Chinese Academy of Sciences, Beijing 100049, China

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For correspondence: ghliu@ioz.ac.cn qujing@ioz.ac.cn zhangwq@big.ac.cn

Guang-Hui Liu

2State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

3Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China

6Institute for Stem cell and Regeneration, CAS, Beijing 100101, China

7University of Chinese Academy of Sciences, Beijing 100049, China