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Germline activity of the heat shock factor HSF-1 programs the insulin-receptor daf-2 in C. elegans

View ORCID ProfileSrijit Das, Sehee Min, View ORCID ProfileVeena Prahlad
doi: https://doi.org/10.1101/2021.02.22.432344
Srijit Das
1Department of Biology, Aging Mind and Brain Initiative, 143 Biology Building, Iowa City, IA 52242-1324
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Sehee Min
1Department of Biology, Aging Mind and Brain Initiative, 143 Biology Building, Iowa City, IA 52242-1324
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Veena Prahlad
1Department of Biology, Aging Mind and Brain Initiative, 143 Biology Building, Iowa City, IA 52242-1324
2Department of Biology, 143 Biology Building, Iowa City, IA 52242-1324
3Iowa Neuroscience Institute, 169 Newton Road, 2312 Pappajohn Biomedical Discovery Building, Iowa City, IA 52242
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  • For correspondence: veena-prahlad@uiowa.edu
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Abstract

The mechanisms by which maternal stress alters offspring phenotypes remain poorly understood. Here we report that the heat shock transcription factor HSF-1, activated in the C. elegans maternal germline upon stress, epigenetically programs the insulin-like receptor daf-2 by increasing repressive H3K9me2 levels throughout the daf-2 gene. This increase occurs by the recruitment of the C. elegans SETDB1 homolog MET-2 by HSF-1. Increased H3K9me2 levels at daf-2 persist in offspring to downregulate daf-2, activate the C. elegans FOXO ortholog DAF-16 and enhance offspring stress resilience. Thus, HSF-1 activity in the mother promotes the early life programming of the insulin/IGF-1 signaling (IIS) pathway and determines the strategy of stress resilience in progeny.

One Sentence Summary HSF-1 recruits MET-2 to silence daf-2 and mediate early life programming of C. elegans upon stress

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 22, 2021.
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Germline activity of the heat shock factor HSF-1 programs the insulin-receptor daf-2 in C. elegans
Srijit Das, Sehee Min, Veena Prahlad
bioRxiv 2021.02.22.432344; doi: https://doi.org/10.1101/2021.02.22.432344
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Germline activity of the heat shock factor HSF-1 programs the insulin-receptor daf-2 in C. elegans
Srijit Das, Sehee Min, Veena Prahlad
bioRxiv 2021.02.22.432344; doi: https://doi.org/10.1101/2021.02.22.432344

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