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Clinically-driven design of synthetic gene regulatory programs in human cells
Divya V. Israni, Hui-Shan Li, Keith A. Gagnon, Jeffry D. Sander, Kole T. Roybal, J. Keith Joung, Wilson W. Wong, View ORCID ProfileAhmad S. Khalil
doi: https://doi.org/10.1101/2021.02.22.432371
Divya V. Israni
1Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, MA 02215, USA
Hui-Shan Li
1Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, MA 02215, USA
Keith A. Gagnon
1Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, MA 02215, USA
Jeffry D. Sander
2Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA
3Department of Pathology, Harvard Medical School, Boston, MA, USA
4Department of Molecular Engineering, Corteva Agriscience™, Johnston IA, 50131, USA
Kole T. Roybal
5Cell Design Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA
6Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, USA
7Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA
8Chan Zuckerberg Biohub, San Francisco, CA, USA
J. Keith Joung
2Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA
3Department of Pathology, Harvard Medical School, Boston, MA, USA
Wilson W. Wong
1Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, MA 02215, USA
Ahmad S. Khalil
1Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, MA 02215, USA
9Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Posted June 07, 2021.
Clinically-driven design of synthetic gene regulatory programs in human cells
Divya V. Israni, Hui-Shan Li, Keith A. Gagnon, Jeffry D. Sander, Kole T. Roybal, J. Keith Joung, Wilson W. Wong, Ahmad S. Khalil
bioRxiv 2021.02.22.432371; doi: https://doi.org/10.1101/2021.02.22.432371
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