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NF-κB-repressed Sirt3 mediates testicular cholesterol metabolism and cytoskeleton assembly via P450scc/SOD2 deacetylation during spermatogenesis

Mei Wang, Ling Zeng, Yao Xiong, Xiao-fei Wang, Lin Cheng, Fang Wang, Ping Su, View ORCID ProfileYuan-zhen Zhang
doi: https://doi.org/10.1101/2021.02.22.432399
Mei Wang
1Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, P.R. China
2Harvard-MGH Center for Reproductive Medicine and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
3Clinical Medicine Research Center of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan 430071, Hubei, P.R. China
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Ling Zeng
4Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R. China
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Yao Xiong
1Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, P.R. China
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Xiao-fei Wang
4Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R. China
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Lin Cheng
1Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, P.R. China
3Clinical Medicine Research Center of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan 430071, Hubei, P.R. China
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Fang Wang
3Clinical Medicine Research Center of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan 430071, Hubei, P.R. China
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Ping Su
4Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R. China
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  • For correspondence: zhangyuanzhen@whu.edu.cn yuanzhenzhangvip@163.com suping24@mails.tjmu.edu.cn
Yuan-zhen Zhang
1Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, P.R. China
3Clinical Medicine Research Center of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan 430071, Hubei, P.R. China
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  • ORCID record for Yuan-zhen Zhang
  • For correspondence: zhangyuanzhen@whu.edu.cn yuanzhenzhangvip@163.com suping24@mails.tjmu.edu.cn
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Article Information

doi 
https://doi.org/10.1101/2021.02.22.432399
History 
  • February 23, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Mei Wang1,2,3,
  2. Ling Zeng4,
  3. Yao Xiong1,
  4. Xiao-fei Wang4,
  5. Lin Cheng1,3,
  6. Fang Wang3,
  7. Ping Su4,* and
  8. Yuan-zhen Zhang1,3,*
  1. 1Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, P.R. China
  2. 2Harvard-MGH Center for Reproductive Medicine and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
  3. 3Clinical Medicine Research Center of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan 430071, Hubei, P.R. China
  4. 4Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R. China
  1. ↵*indicates corresponding authors First corresponding author:
    Yuan-zhen Zhang: zhangyuanzhen{at}whu.edu.cn; yuanzhenzhangvip{at}163.com; Second corresponding author:
    Ping Su: suping24{at}mails.tjmu.edu.cn;
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Posted February 23, 2021.
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NF-κB-repressed Sirt3 mediates testicular cholesterol metabolism and cytoskeleton assembly via P450scc/SOD2 deacetylation during spermatogenesis
Mei Wang, Ling Zeng, Yao Xiong, Xiao-fei Wang, Lin Cheng, Fang Wang, Ping Su, Yuan-zhen Zhang
bioRxiv 2021.02.22.432399; doi: https://doi.org/10.1101/2021.02.22.432399
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NF-κB-repressed Sirt3 mediates testicular cholesterol metabolism and cytoskeleton assembly via P450scc/SOD2 deacetylation during spermatogenesis
Mei Wang, Ling Zeng, Yao Xiong, Xiao-fei Wang, Lin Cheng, Fang Wang, Ping Su, Yuan-zhen Zhang
bioRxiv 2021.02.22.432399; doi: https://doi.org/10.1101/2021.02.22.432399

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