Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

A synaptic novelty signal to switch hippocampal attractor networks from generalization to discrimination

View ORCID ProfileRuy Gómez-Ocádiz, View ORCID ProfileMassimiliano Trippa, View ORCID ProfileLorenzo Posani, View ORCID ProfileSimona Cocco, View ORCID ProfileRémi Monasson, View ORCID ProfileChristoph Schmidt-Hieber
doi: https://doi.org/10.1101/2021.02.24.432612
Ruy Gómez-Ocádiz
1Department of Neuroscience, Institut Pasteur, 25 Rue du Dr Roux, 75015 Paris, France
4Sorbonne Université, Collège Doctoral, 75005 Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ruy Gómez-Ocádiz
Massimiliano Trippa
2Laboratory of Physics of the École Normale Supérieure, PSL Research and CNRS UMR 8023, Sorbonne Université, Université de Paris, 24 Rue Lhomond, 75005 Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Massimiliano Trippa
Lorenzo Posani
1Department of Neuroscience, Institut Pasteur, 25 Rue du Dr Roux, 75015 Paris, France
3Center for Theoretical Neuroscience, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Lorenzo Posani
Simona Cocco
2Laboratory of Physics of the École Normale Supérieure, PSL Research and CNRS UMR 8023, Sorbonne Université, Université de Paris, 24 Rue Lhomond, 75005 Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Simona Cocco
Rémi Monasson
2Laboratory of Physics of the École Normale Supérieure, PSL Research and CNRS UMR 8023, Sorbonne Université, Université de Paris, 24 Rue Lhomond, 75005 Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Rémi Monasson
Christoph Schmidt-Hieber
1Department of Neuroscience, Institut Pasteur, 25 Rue du Dr Roux, 75015 Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Christoph Schmidt-Hieber
  • For correspondence: christoph.schmidt-hieber@pasteur.fr
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Episodic memory formation and recall are complementary processes that put conflicting requirements on neuronal computations in the hippocampus. How this challenge is resolved in hippocampal circuits is unclear. To address this question, we obtained in vivo whole-cell patch-clamp recordings from dentate gyrus granule cells in head-fixed mice trained to explore and distinguish between familiar and novel virtual environments. We find that granule cells consistently show a small transient depolarization of their membrane potential upon transition to a novel environment. This synaptic novelty signal is sensitive to local application of atropine, indicating that it depends on metabotropic acetylcholine receptors. A computational model suggests that the observed transient synaptic response to novel environments may lead to a bias in the granule cell population activity, which can in turn drive the downstream attractor networks to a new state, thereby favoring the switch from generalization to discrimination when faced with novelty. Such a novelty-driven cholinergic switch may enable flexible encoding of new memories while preserving stable retrieval of familiar ones.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Added new discussion about cholinergic inputs to the dentate gyrus.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted April 02, 2021.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
A synaptic novelty signal to switch hippocampal attractor networks from generalization to discrimination
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
A synaptic novelty signal to switch hippocampal attractor networks from generalization to discrimination
Ruy Gómez-Ocádiz, Massimiliano Trippa, Lorenzo Posani, Simona Cocco, Rémi Monasson, Christoph Schmidt-Hieber
bioRxiv 2021.02.24.432612; doi: https://doi.org/10.1101/2021.02.24.432612
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
A synaptic novelty signal to switch hippocampal attractor networks from generalization to discrimination
Ruy Gómez-Ocádiz, Massimiliano Trippa, Lorenzo Posani, Simona Cocco, Rémi Monasson, Christoph Schmidt-Hieber
bioRxiv 2021.02.24.432612; doi: https://doi.org/10.1101/2021.02.24.432612

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (3580)
  • Biochemistry (7534)
  • Bioengineering (5488)
  • Bioinformatics (20709)
  • Biophysics (10267)
  • Cancer Biology (7942)
  • Cell Biology (11597)
  • Clinical Trials (138)
  • Developmental Biology (6576)
  • Ecology (10151)
  • Epidemiology (2065)
  • Evolutionary Biology (13565)
  • Genetics (9504)
  • Genomics (12801)
  • Immunology (7891)
  • Microbiology (19472)
  • Molecular Biology (7624)
  • Neuroscience (41939)
  • Paleontology (307)
  • Pathology (1253)
  • Pharmacology and Toxicology (2182)
  • Physiology (3254)
  • Plant Biology (7017)
  • Scientific Communication and Education (1291)
  • Synthetic Biology (1944)
  • Systems Biology (5412)
  • Zoology (1109)