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Disrupted circadian core-clock oscillations in Type 2 Diabetes are linked to altered rhythmic mitochondrial metabolism
View ORCID ProfileBrendan M. Gabriel, Ali Altıntaş, Jonathon A.B. Smith, View ORCID ProfileLaura Sardon-Puig, Xiping Zhang, Astrid L. Basse, View ORCID ProfileRhianna C. Laker, Hui Gao, Zhengye Liu, View ORCID ProfileLucile Dollet, Jonas T. Treebak, Antonio Zorzano, Zhiguang Huo, View ORCID ProfileMikael Rydén, View ORCID ProfileJohanna T. Lanner, View ORCID ProfileKaryn A. Esser, View ORCID ProfileRomain Barrès, View ORCID ProfileNicolas J. Pillon, Anna Krook, View ORCID ProfileJuleen R. Zierath
doi: https://doi.org/10.1101/2021.02.24.432683
Brendan M. Gabriel
1Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
2Aberdeen Cardiovascular & Diabetes Centre, The Rowett Institute, University of Aberdeen, Aberdeen, UK
Ali Altıntaş
3Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Jonathon A.B. Smith
1Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
Laura Sardon-Puig
4Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
Xiping Zhang
5Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Florida, USA
Astrid L. Basse
3Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Rhianna C. Laker
3Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Hui Gao
6Department of Biosciences and Nutrition (BioNut), Karolinska Institutet, Stockholm, Sweden
Zhengye Liu
12Department of Physiology and Pharmacology, Molecular muscle physiology & pathophysiology, Karolinska Institutet, Stockholm, Sweden
Lucile Dollet
1Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
Jonas T. Treebak
3Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Antonio Zorzano
7Institute for Research in Biomedicine (IRB Barcelona). The Barcelona Institute of Science and Technology, Barcelona, Spain
8Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Barcelona, Spain
9CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Spain
Zhiguang Huo
10Department of Biostatistics, University of Florida, Florida, USA
Mikael Rydén
11Department of Medicine (H7), Unit for Endocrinology and Diabetes, Karolinska Institutet, Stockholm, Sweden
Johanna T. Lanner
12Department of Physiology and Pharmacology, Molecular muscle physiology & pathophysiology, Karolinska Institutet, Stockholm, Sweden
Karyn A. Esser
5Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Florida, USA
Romain Barrès
3Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Nicolas J. Pillon
1Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
Anna Krook
1Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
Juleen R. Zierath
1Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
3Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
4Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
Article usage
Posted February 25, 2021.
Disrupted circadian core-clock oscillations in Type 2 Diabetes are linked to altered rhythmic mitochondrial metabolism
Brendan M. Gabriel, Ali Altıntaş, Jonathon A.B. Smith, Laura Sardon-Puig, Xiping Zhang, Astrid L. Basse, Rhianna C. Laker, Hui Gao, Zhengye Liu, Lucile Dollet, Jonas T. Treebak, Antonio Zorzano, Zhiguang Huo, Mikael Rydén, Johanna T. Lanner, Karyn A. Esser, Romain Barrès, Nicolas J. Pillon, Anna Krook, Juleen R. Zierath
bioRxiv 2021.02.24.432683; doi: https://doi.org/10.1101/2021.02.24.432683
Disrupted circadian core-clock oscillations in Type 2 Diabetes are linked to altered rhythmic mitochondrial metabolism
Brendan M. Gabriel, Ali Altıntaş, Jonathon A.B. Smith, Laura Sardon-Puig, Xiping Zhang, Astrid L. Basse, Rhianna C. Laker, Hui Gao, Zhengye Liu, Lucile Dollet, Jonas T. Treebak, Antonio Zorzano, Zhiguang Huo, Mikael Rydén, Johanna T. Lanner, Karyn A. Esser, Romain Barrès, Nicolas J. Pillon, Anna Krook, Juleen R. Zierath
bioRxiv 2021.02.24.432683; doi: https://doi.org/10.1101/2021.02.24.432683
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