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Selection of active defensive behaviors relies on extended amygdala dopamine D2 receptors

View ORCID ProfileLaia Castell, View ORCID ProfileValentine Le Gall, View ORCID ProfileLaura Cutando, View ORCID ProfileEmma Puighermanal, View ORCID ProfileDaniel Jercog, Pauline Tarot, Adrien Tassou, View ORCID ProfileAnne-Gabrielle Harrus, Marcelo Rubinstein, View ORCID ProfileRégis Nouvian, View ORCID ProfileCyril Rivat, View ORCID ProfileCyril Herry, View ORCID ProfileEmmanuel Valjent
doi: https://doi.org/10.1101/2021.02.24.432692
Laia Castell
1IGF, Univ. Montpellier, CNRS, Inserm, F-34094 Montpellier, France
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  • ORCID record for Laia Castell
  • For correspondence: laia.castell.almuni@gmail.com emmanuel.valjent@igf.cnrs.fr
Valentine Le Gall
2Université de Bordeaux, Neurocentre Magendie, U1215, F-33077 Bordeaux, France
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  • ORCID record for Valentine Le Gall
Laura Cutando
1IGF, Univ. Montpellier, CNRS, Inserm, F-34094 Montpellier, France
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  • ORCID record for Laura Cutando
Emma Puighermanal
1IGF, Univ. Montpellier, CNRS, Inserm, F-34094 Montpellier, France
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  • ORCID record for Emma Puighermanal
Daniel Jercog
2Université de Bordeaux, Neurocentre Magendie, U1215, F-33077 Bordeaux, France
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Pauline Tarot
1IGF, Univ. Montpellier, CNRS, Inserm, F-34094 Montpellier, France
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Adrien Tassou
3INM, Univ. Montpellier, Inserm, F-34000 Montpellier, France.
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Anne-Gabrielle Harrus
3INM, Univ. Montpellier, Inserm, F-34000 Montpellier, France.
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  • ORCID record for Anne-Gabrielle Harrus
Marcelo Rubinstein
4Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, CONICET; FCEN, Universidad de Buenos Aires, Buenos Aires, Argentina; and Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA
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Régis Nouvian
3INM, Univ. Montpellier, Inserm, F-34000 Montpellier, France.
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  • ORCID record for Régis Nouvian
Cyril Rivat
3INM, Univ. Montpellier, Inserm, F-34000 Montpellier, France.
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  • ORCID record for Cyril Rivat
Cyril Herry
2Université de Bordeaux, Neurocentre Magendie, U1215, F-33077 Bordeaux, France
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Emmanuel Valjent
1IGF, Univ. Montpellier, CNRS, Inserm, F-34094 Montpellier, France
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  • ORCID record for Emmanuel Valjent
  • For correspondence: laia.castell.almuni@gmail.com emmanuel.valjent@igf.cnrs.fr
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Summary

The ability to efficiently switch from one defensive strategy to another maximizes an animal’s chance of survival. Here, we demonstrate that the selection of active defensive behaviors requires the coordinated activation of dopamine D2 receptor (D2R) signaling within the central extended amygdala (EA) comprising the nucleus accumbens, the oval bed nucleus stria terminals and the central amygdala. We find that discriminative learning between predictive and non-predictive threat auditory stimuli is unaltered in mice carrying a temporally-controlled deletion of D2R within output neurons of the EA. In contrast, intact EA D2R signaling is required for active avoidance learning and innate flight responses triggered by a visual threat stimulus (looming). Consequently, conditional D2R knockout mice biased defensive responses toward passive defensive strategies. Altogether, these findings identify EA D2R signaling as an important mechanism by which DA regulates the switch from passive to active defensive behaviors, regardless whether of learned or innate threat.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted February 24, 2021.
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Selection of active defensive behaviors relies on extended amygdala dopamine D2 receptors
Laia Castell, Valentine Le Gall, Laura Cutando, Emma Puighermanal, Daniel Jercog, Pauline Tarot, Adrien Tassou, Anne-Gabrielle Harrus, Marcelo Rubinstein, Régis Nouvian, Cyril Rivat, Cyril Herry, Emmanuel Valjent
bioRxiv 2021.02.24.432692; doi: https://doi.org/10.1101/2021.02.24.432692
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Selection of active defensive behaviors relies on extended amygdala dopamine D2 receptors
Laia Castell, Valentine Le Gall, Laura Cutando, Emma Puighermanal, Daniel Jercog, Pauline Tarot, Adrien Tassou, Anne-Gabrielle Harrus, Marcelo Rubinstein, Régis Nouvian, Cyril Rivat, Cyril Herry, Emmanuel Valjent
bioRxiv 2021.02.24.432692; doi: https://doi.org/10.1101/2021.02.24.432692

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