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Microglia become hypofunctional and release metalloproteases and tau seeds after phagocytosing live neurons with P301S tau aggregates

Jack H. Brelstaff, Matthew Mason, Taxiarchis Katsinelos, William A. McEwan, Bernardino Ghetti, Aviva M. Tolkovsky, Maria Grazia Spillantini
doi: https://doi.org/10.1101/2021.02.26.433088
Jack H. Brelstaff
1Department of Clinical Neurosciences, Clifford Allbutt Building, University of Cambridge, Cambridge, CB2 0AH, UK
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Matthew Mason
1Department of Clinical Neurosciences, Clifford Allbutt Building, University of Cambridge, Cambridge, CB2 0AH, UK
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Taxiarchis Katsinelos
1Department of Clinical Neurosciences, Clifford Allbutt Building, University of Cambridge, Cambridge, CB2 0AH, UK
2UK Dementia Research Institute Cambridge, Island Research Building, University of Cambridge, Cambridge, CB2 0AH, UK
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William A. McEwan
1Department of Clinical Neurosciences, Clifford Allbutt Building, University of Cambridge, Cambridge, CB2 0AH, UK
2UK Dementia Research Institute Cambridge, Island Research Building, University of Cambridge, Cambridge, CB2 0AH, UK
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Bernardino Ghetti
3Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA
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Aviva M. Tolkovsky
1Department of Clinical Neurosciences, Clifford Allbutt Building, University of Cambridge, Cambridge, CB2 0AH, UK
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  • For correspondence: mgs11@cam.ac.uk amt1004@cam.ac.uk
Maria Grazia Spillantini
1Department of Clinical Neurosciences, Clifford Allbutt Building, University of Cambridge, Cambridge, CB2 0AH, UK
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  • For correspondence: mgs11@cam.ac.uk amt1004@cam.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2021.02.26.433088
History 
  • February 26, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Jack H. Brelstaff1,
  2. Matthew Mason1,
  3. Taxiarchis Katsinelos1,2,
  4. William A. McEwan1,2,
  5. Bernardino Ghetti3,
  6. Aviva M. Tolkovsky1,* and
  7. Maria Grazia Spillantini1,*
  1. 1Department of Clinical Neurosciences, Clifford Allbutt Building, University of Cambridge, Cambridge, CB2 0AH, UK
  2. 2UK Dementia Research Institute Cambridge, Island Research Building, University of Cambridge, Cambridge, CB2 0AH, UK
  3. 3Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA
  1. ↵*Correspondence, Maria Grazia Spillantini, mgs11{at}cam.ac.uk, Aviva M. Tolkovsky, amt1004{at}cam.ac.uk
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Posted February 26, 2021.
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Microglia become hypofunctional and release metalloproteases and tau seeds after phagocytosing live neurons with P301S tau aggregates
Jack H. Brelstaff, Matthew Mason, Taxiarchis Katsinelos, William A. McEwan, Bernardino Ghetti, Aviva M. Tolkovsky, Maria Grazia Spillantini
bioRxiv 2021.02.26.433088; doi: https://doi.org/10.1101/2021.02.26.433088
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Microglia become hypofunctional and release metalloproteases and tau seeds after phagocytosing live neurons with P301S tau aggregates
Jack H. Brelstaff, Matthew Mason, Taxiarchis Katsinelos, William A. McEwan, Bernardino Ghetti, Aviva M. Tolkovsky, Maria Grazia Spillantini
bioRxiv 2021.02.26.433088; doi: https://doi.org/10.1101/2021.02.26.433088

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