Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees

Alison Tarke; John Sidney; Nils Methot; Yun Zhang; Jennifer M. Dan; Benjamin Goodwin; Paul Rubiro; Aaron Sutherland; Ricardo da Silva Antunes; April Frazier; Stephen A. Rawlings; Davey M. Smith; Bjoern Peters; Richard H. Scheuermann; Daniela Weiskopf; Shane Crotty; Alba Grifoni; Alessandro Sette

doi:10.1101/2021.02.27.433180

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Negligible impact of SARS-CoV-2 variants on CD4⁺ and CD8⁺ T cell reactivity in COVID-19 exposed donors and vaccinees

Alison Tarke, John Sidney, Nils Methot, View ORCID ProfileYun Zhang, View ORCID ProfileJennifer M. Dan, Benjamin Goodwin, Paul Rubiro, Aaron Sutherland, View ORCID ProfileRicardo da Silva Antunes, April Frazier, Stephen A. Rawlings, Davey M. Smith, Bjoern Peters, Richard H. Scheuermann, Daniela Weiskopf, View ORCID ProfileShane Crotty, View ORCID ProfileAlba Grifoni, Alessandro Sette

doi: https://doi.org/10.1101/2021.02.27.433180

Alison Tarke

1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA

2Department of Internal Medicine and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, 16132, Italy

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John Sidney

1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA

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Nils Methot

1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA

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Yun Zhang

4J. Craig Venter Institute, La Jolla, CA 92037, USA

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Jennifer M. Dan

1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA

3Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA

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Benjamin Goodwin

1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA

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Paul Rubiro

1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA

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Aaron Sutherland

1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA

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Ricardo da Silva Antunes

1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA

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April Frazier

1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA

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Stephen A. Rawlings

3Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA

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Davey M. Smith

3Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA

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Bjoern Peters

1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA

3Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA

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Richard H. Scheuermann

1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA

4J. Craig Venter Institute, La Jolla, CA 92037, USA

5Department of Pathology, University of California, San Diego, CA 92093

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Daniela Weiskopf

1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA

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Shane Crotty

1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA

3Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA

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Alba Grifoni

1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA

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For correspondence: alex@lji.org agrifoni@lji.org

Alessandro Sette

1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA

3Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA

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For correspondence: alex@lji.org agrifoni@lji.org

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Posted March 01, 2021.

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Negligible impact of SARS-CoV-2 variants on CD4⁺ and CD8⁺ T cell reactivity in COVID-19 exposed donors and vaccinees

Alison Tarke, John Sidney, Nils Methot, Yun Zhang, Jennifer M. Dan, Benjamin Goodwin, Paul Rubiro, Aaron Sutherland, Ricardo da Silva Antunes, April Frazier, Stephen A. Rawlings, Davey M. Smith, Bjoern Peters, Richard H. Scheuermann, Daniela Weiskopf, Shane Crotty, Alba Grifoni, Alessandro Sette

bioRxiv 2021.02.27.433180; doi: https://doi.org/10.1101/2021.02.27.433180

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