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Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes
Susheel K. Gunasekar, Litao Xie, Pratik R. Chheda, Chen Kang, David M. Kern, Chau My-Ta, Ashutosh Kumar, Joshua Maurer, Eva E. Gerber, Wojciech J. Grzesik, Macaulay Elliot-Hudson, Yanhui Zhang, Chaitanya A. Kulkarni, Isaac Samuel, Jessica K. Smith, Peter Nau, Yumi Imai, Ryan D. Sheldon, Eric B. Taylor, Daniel J. Lerner, Andrew W. Norris, Stephen G. Brohawn, Robert Kerns, Rajan Sah
doi: https://doi.org/10.1101/2021.02.28.432901
Susheel K. Gunasekar
1Department of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA
Litao Xie
1Department of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA
Pratik R. Chheda
2Department of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa, College of Pharmacy, Iowa City, IA, USA
Chen Kang
1Department of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA
David M. Kern
3Department of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA, USA
4Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA
Chau My-Ta
5Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Ashutosh Kumar
1Department of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA
Joshua Maurer
1Department of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA
Eva E. Gerber
3Department of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA, USA
4Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA
Wojciech J. Grzesik
6Stead Family Department of Pediatrics, Endocrinology and Diabetes Division, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA
Macaulay Elliot-Hudson
7Department of Internal Medicine, Cardiovascular Division, University of Iowa, Iowa City, IA, USA
Yanhui Zhang
8Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, China
Chaitanya A. Kulkarni
2Department of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa, College of Pharmacy, Iowa City, IA, USA
Isaac Samuel
9Department of Surgery, University of Iowa, Carver College of Medicine, Iowa City, IA, USA
Jessica K. Smith
9Department of Surgery, University of Iowa, Carver College of Medicine, Iowa City, IA, USA
Peter Nau
9Department of Surgery, University of Iowa, Carver College of Medicine, Iowa City, IA, USA
Yumi Imai
7Department of Internal Medicine, Cardiovascular Division, University of Iowa, Iowa City, IA, USA
Ryan D. Sheldon
10Department of Biochemistry, University of Iowa, Iowa City, IA, USA
Eric B. Taylor
10Department of Biochemistry, University of Iowa, Iowa City, IA, USA
Daniel J. Lerner
11Senseion Therapeutics Inc., St Louis, MO.
Andrew W. Norris
6Stead Family Department of Pediatrics, Endocrinology and Diabetes Division, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA
Stephen G. Brohawn
3Department of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA, USA
4Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA
Robert Kerns
2Department of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa, College of Pharmacy, Iowa City, IA, USA
Rajan Sah
1Department of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA
Article usage
Posted March 02, 2021.
Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes
Susheel K. Gunasekar, Litao Xie, Pratik R. Chheda, Chen Kang, David M. Kern, Chau My-Ta, Ashutosh Kumar, Joshua Maurer, Eva E. Gerber, Wojciech J. Grzesik, Macaulay Elliot-Hudson, Yanhui Zhang, Chaitanya A. Kulkarni, Isaac Samuel, Jessica K. Smith, Peter Nau, Yumi Imai, Ryan D. Sheldon, Eric B. Taylor, Daniel J. Lerner, Andrew W. Norris, Stephen G. Brohawn, Robert Kerns, Rajan Sah
bioRxiv 2021.02.28.432901; doi: https://doi.org/10.1101/2021.02.28.432901
Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes
Susheel K. Gunasekar, Litao Xie, Pratik R. Chheda, Chen Kang, David M. Kern, Chau My-Ta, Ashutosh Kumar, Joshua Maurer, Eva E. Gerber, Wojciech J. Grzesik, Macaulay Elliot-Hudson, Yanhui Zhang, Chaitanya A. Kulkarni, Isaac Samuel, Jessica K. Smith, Peter Nau, Yumi Imai, Ryan D. Sheldon, Eric B. Taylor, Daniel J. Lerner, Andrew W. Norris, Stephen G. Brohawn, Robert Kerns, Rajan Sah
bioRxiv 2021.02.28.432901; doi: https://doi.org/10.1101/2021.02.28.432901
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