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Day-night and seasonal variation of human gene expression across tissues

View ORCID ProfileValentin Wucher, Reza Sodaei, Raziel Amador, View ORCID ProfileManuel Irimia, Roderic Guigó
doi: https://doi.org/10.1101/2021.02.28.433266
Valentin Wucher
1Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain
2NeuroMyogene Institute, SynatAc Team, INSERM U1217/UMR CNRS 5310, Lyon, France
3French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Lyon, France
4University of Lyon, Université Claude Bernard Lyon 1, Lyon, France
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  • ORCID record for Valentin Wucher
Reza Sodaei
1Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain
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Raziel Amador
1Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain
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Manuel Irimia
1Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain
5Universitat Pompeu Fabra, Barcelona, Spain
6ICREA, Barcelona, Spain
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  • For correspondence: mirimia@gmail.com roderic.guigo@crg.eu
Roderic Guigó
1Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain
5Universitat Pompeu Fabra, Barcelona, Spain
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  • For correspondence: mirimia@gmail.com roderic.guigo@crg.eu
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Abstract

Circadian and circannual cycles trigger physiological changes whose reflection on human transcriptomes remains largely uncharted. We used the time and season of death of 932 individuals from GTEx to jointly investigate transcriptomic changes associated with those cycles across multiple tissues. Overall, most variation across tissues during day-night and among seasons was unique to each cycle. Although all tissues remodeled their transcriptomes, brain and gonadal tissues exhibited the highest seasonality, whereas those in the thoracic cavity showed stronger day-night regulation. Core clock genes displayed marked day-night differences across multiple tissues, which were largely conserved in baboon and mouse, but adapted to their nocturnal or diurnal habits. Seasonal variation of expression affected multiple pathways and it was enriched among genes associated with the immune response, consistent with the seasonality of viral infections. Furthermore, they unveiled cytoarchitectural changes in brain regions. Altogether, our results provide the first combined atlas of how transcriptomes from human tissues adapt to major cycling environmental conditions.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵7 Co-first authors.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted January 11, 2022.
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Day-night and seasonal variation of human gene expression across tissues
Valentin Wucher, Reza Sodaei, Raziel Amador, Manuel Irimia, Roderic Guigó
bioRxiv 2021.02.28.433266; doi: https://doi.org/10.1101/2021.02.28.433266
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Day-night and seasonal variation of human gene expression across tissues
Valentin Wucher, Reza Sodaei, Raziel Amador, Manuel Irimia, Roderic Guigó
bioRxiv 2021.02.28.433266; doi: https://doi.org/10.1101/2021.02.28.433266

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