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A ciliopathy complex builds distal appendages to initiate ciliogenesis

View ORCID ProfileDhivya Kumar, Addison Rains, Vicente Herranz-Pérez, Quanlong Lu, Xiaoyu Shi, Danielle L. Swaney, Erica Stevenson, Nevan J. Krogan, Bo Huang, Christopher Westlake, Jose Manuel Garcia-Verdugo, Bradley Yoder, Jeremy F. Reiter
doi: https://doi.org/10.1101/2021.03.01.433418
Dhivya Kumar
1Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA
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  • ORCID record for Dhivya Kumar
Addison Rains
2Department of Cell, Developmental, and Integrative Biology, University of Alabama, Birmingham
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Vicente Herranz-Pérez
3Laboratory of Comparative Neurobiology, Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia, CIBERNED, 46980 Valencia, Spain
4Predepartamental Unit of Medicine, Faculty of Health Sciences, Universitat Jaume I, 12071 Castelló de la Plana, Spain
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Quanlong Lu
11Center for Cancer Research, NCI Frederick, Laboratory of Cellular and Developmental Signaling, Frederick, MD 21702, USA.
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Xiaoyu Shi
5Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143 USA
6Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92697 USA
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Danielle L. Swaney
8Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA
9California Institute for Quantitative Biosciences, QBI, University of California, San Francisco, San Francisco, CA 94158, USA
10J. David Gladstone Institutes, San Francisco, CA 94158, USA
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Erica Stevenson
8Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA
9California Institute for Quantitative Biosciences, QBI, University of California, San Francisco, San Francisco, CA 94158, USA
10J. David Gladstone Institutes, San Francisco, CA 94158, USA
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Nevan J. Krogan
8Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA
9California Institute for Quantitative Biosciences, QBI, University of California, San Francisco, San Francisco, CA 94158, USA
10J. David Gladstone Institutes, San Francisco, CA 94158, USA
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Bo Huang
5Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143 USA
7Chan Zuckerberg Biohub, San Francisco, CA 94158, USA
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Christopher Westlake
11Center for Cancer Research, NCI Frederick, Laboratory of Cellular and Developmental Signaling, Frederick, MD 21702, USA.
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Jose Manuel Garcia-Verdugo
3Laboratory of Comparative Neurobiology, Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia, CIBERNED, 46980 Valencia, Spain
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Bradley Yoder
2Department of Cell, Developmental, and Integrative Biology, University of Alabama, Birmingham
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Jeremy F. Reiter
1Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA
7Chan Zuckerberg Biohub, San Francisco, CA 94158, USA
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  • For correspondence: Jeremy.Reiter@ucsf.edu
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Article Information

doi 
https://doi.org/10.1101/2021.03.01.433418
History 
  • March 1, 2021.

Article Versions

  • You are currently viewing Version 1 of this article (March 1, 2021 - 14:54).
  • View Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Dhivya Kumar1,
  2. Addison Rains2,
  3. Vicente Herranz-Pérez3,4,
  4. Quanlong Lu11,
  5. Xiaoyu Shi5,6,
  6. Danielle L. Swaney8,9,10,
  7. Erica Stevenson8,9,10,
  8. Nevan J. Krogan8,9,10,
  9. Bo Huang5,7,
  10. Christopher Westlake11,
  11. Jose Manuel Garcia-Verdugo3,
  12. Bradley Yoder2 and
  13. Jeremy F. Reiter1,7,*
  1. 1Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA
  2. 2Department of Cell, Developmental, and Integrative Biology, University of Alabama, Birmingham
  3. 3Laboratory of Comparative Neurobiology, Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia, CIBERNED, 46980 Valencia, Spain
  4. 4Predepartamental Unit of Medicine, Faculty of Health Sciences, Universitat Jaume I, 12071 Castelló de la Plana, Spain
  5. 5Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143 USA
  6. 6Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92697 USA
  7. 7Chan Zuckerberg Biohub, San Francisco, CA 94158, USA
  8. 8Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA
  9. 9California Institute for Quantitative Biosciences, QBI, University of California, San Francisco, San Francisco, CA 94158, USA
  10. 10J. David Gladstone Institutes, San Francisco, CA 94158, USA
  11. 11Center for Cancer Research, NCI Frederick, Laboratory of Cellular and Developmental Signaling, Frederick, MD 21702, USA.
  1. ↵*Correspondence: Jeremy.Reiter{at}ucsf.edu
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A ciliopathy complex builds distal appendages to initiate ciliogenesis
Dhivya Kumar, Addison Rains, Vicente Herranz-Pérez, Quanlong Lu, Xiaoyu Shi, Danielle L. Swaney, Erica Stevenson, Nevan J. Krogan, Bo Huang, Christopher Westlake, Jose Manuel Garcia-Verdugo, Bradley Yoder, Jeremy F. Reiter
bioRxiv 2021.03.01.433418; doi: https://doi.org/10.1101/2021.03.01.433418
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A ciliopathy complex builds distal appendages to initiate ciliogenesis
Dhivya Kumar, Addison Rains, Vicente Herranz-Pérez, Quanlong Lu, Xiaoyu Shi, Danielle L. Swaney, Erica Stevenson, Nevan J. Krogan, Bo Huang, Christopher Westlake, Jose Manuel Garcia-Verdugo, Bradley Yoder, Jeremy F. Reiter
bioRxiv 2021.03.01.433418; doi: https://doi.org/10.1101/2021.03.01.433418

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