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Vaccination with SARS-CoV-2 Spike Protein and AS03 Adjuvant Induces Rapid Anamnestic Antibodies in the Lung and Protects Against Virus Challenge in Nonhuman Primates
Joseph R. Francica, Barbara J. Flynn, Kathryn E. Foulds, Amy T. Noe, Anne P. Werner, Ian N. Moore, Matthew Gagne, Timothy S. Johnston, Courtney Tucker, Rachel L. Davis, Britta Flach, Sarah O’Connell, Shayne F. Andrew, Evan Lamb, Dillon R. Flebbe, Saule T. Nurmukhambetova, Mitzi M. Donaldson, John-Paul M. Todd, Alex Lee Zhu, Caroline Atyeo, Stephanie Fischinger, Matthew J Gorman, Sally Shin, Venkata Viswanadh Edara, Katharine Floyd, Lilin Lai, Alida Tylor, Elizabeth McCarthy, Valerie Lecouturier, Sophie Ruiz, Catherine Berry, Timothy Tibbitts, Hanne Andersen, Anthony Cook, Alan Dodson, Laurent Pessaint, Alex Van Ry, Marguerite Koutsoukos, Cindy Gutzeit, I-Ting Teng, Tongqing Zhou, Dapeng Li, Barton F. Haynes, Peter D. Kwong, Adrian McDermott, Mark G. Lewis, Tong Ming Fu, Roman Chicz, Robbert van der Most, Kizzmekia S. Corbett, Mehul S. Suthar, Galit Alter, Mario Roederer, Nancy J. Sullivan, Daniel C. Douek, Barney S. Graham, Danilo Casimiro, Robert A. Seder
doi: https://doi.org/10.1101/2021.03.02.433390
Joseph R. Francica
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Barbara J. Flynn
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Kathryn E. Foulds
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Amy T. Noe
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Anne P. Werner
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Ian N. Moore
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Matthew Gagne
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Timothy S. Johnston
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Courtney Tucker
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Rachel L. Davis
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Britta Flach
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Sarah O’Connell
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Shayne F. Andrew
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Evan Lamb
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Dillon R. Flebbe
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Saule T. Nurmukhambetova
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Mitzi M. Donaldson
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
John-Paul M. Todd
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Alex Lee Zhu
2Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
3PhD program in Immunology and Virology, University of Duisburg-Essen, Essen, Germany
Caroline Atyeo
2Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
4PhD program in Virology, Division of Medical Sciences, Harvard University, Boston, MA, USA
Stephanie Fischinger
2Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
3PhD program in Immunology and Virology, University of Duisburg-Essen, Essen, Germany
Matthew J Gorman
2Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
Sally Shin
2Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
Venkata Viswanadh Edara
5Centers for Childhood Infections and Vaccines; Children’s Healthcare of Atlanta and Emory University, Department of Pediatrics, Atlanta, GA, 30329, USA
6Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA
7Yerkes National Primate Research Center, Atlanta, GA 30329, USA
Katharine Floyd
5Centers for Childhood Infections and Vaccines; Children’s Healthcare of Atlanta and Emory University, Department of Pediatrics, Atlanta, GA, 30329, USA
6Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA
7Yerkes National Primate Research Center, Atlanta, GA 30329, USA
Lilin Lai
5Centers for Childhood Infections and Vaccines; Children’s Healthcare of Atlanta and Emory University, Department of Pediatrics, Atlanta, GA, 30329, USA
6Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA
7Yerkes National Primate Research Center, Atlanta, GA 30329, USA
Alida Tylor
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Elizabeth McCarthy
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Valerie Lecouturier
8Sanofi Pasteur, Marcy l’Etoile, France
Sophie Ruiz
8Sanofi Pasteur, Marcy l’Etoile, France
Catherine Berry
8Sanofi Pasteur, Marcy l’Etoile, France
Timothy Tibbitts
9Sanofi Pasteur, 38 Sidney Street, Cambridge, MA 02139, USA
Hanne Andersen
10Bioqual, Inc., Rockville, MD, USA
Anthony Cook
10Bioqual, Inc., Rockville, MD, USA
Alan Dodson
10Bioqual, Inc., Rockville, MD, USA
Laurent Pessaint
10Bioqual, Inc., Rockville, MD, USA
Alex Van Ry
10Bioqual, Inc., Rockville, MD, USA
Marguerite Koutsoukos
11GSK, Wavre, Belgium
Cindy Gutzeit
12GSK, Rixensart, Belgium
I-Ting Teng
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Tongqing Zhou
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Dapeng Li
13Duke Human Vaccine Institute, Duke University, Durham, NC 27708, USA
Barton F. Haynes
13Duke Human Vaccine Institute, Duke University, Durham, NC 27708, USA
Peter D. Kwong
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Adrian McDermott
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Mark G. Lewis
10Bioqual, Inc., Rockville, MD, USA
Tong Ming Fu
9Sanofi Pasteur, 38 Sidney Street, Cambridge, MA 02139, USA
Roman Chicz
9Sanofi Pasteur, 38 Sidney Street, Cambridge, MA 02139, USA
Robbert van der Most
12GSK, Rixensart, Belgium
Kizzmekia S. Corbett
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Mehul S. Suthar
5Centers for Childhood Infections and Vaccines; Children’s Healthcare of Atlanta and Emory University, Department of Pediatrics, Atlanta, GA, 30329, USA
6Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA
7Yerkes National Primate Research Center, Atlanta, GA 30329, USA
Galit Alter
2Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
Mario Roederer
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Nancy J. Sullivan
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Daniel C. Douek
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Barney S. Graham
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Danilo Casimiro
9Sanofi Pasteur, 38 Sidney Street, Cambridge, MA 02139, USA
Robert A. Seder
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Article usage
Posted March 02, 2021.
Vaccination with SARS-CoV-2 Spike Protein and AS03 Adjuvant Induces Rapid Anamnestic Antibodies in the Lung and Protects Against Virus Challenge in Nonhuman Primates
Joseph R. Francica, Barbara J. Flynn, Kathryn E. Foulds, Amy T. Noe, Anne P. Werner, Ian N. Moore, Matthew Gagne, Timothy S. Johnston, Courtney Tucker, Rachel L. Davis, Britta Flach, Sarah O’Connell, Shayne F. Andrew, Evan Lamb, Dillon R. Flebbe, Saule T. Nurmukhambetova, Mitzi M. Donaldson, John-Paul M. Todd, Alex Lee Zhu, Caroline Atyeo, Stephanie Fischinger, Matthew J Gorman, Sally Shin, Venkata Viswanadh Edara, Katharine Floyd, Lilin Lai, Alida Tylor, Elizabeth McCarthy, Valerie Lecouturier, Sophie Ruiz, Catherine Berry, Timothy Tibbitts, Hanne Andersen, Anthony Cook, Alan Dodson, Laurent Pessaint, Alex Van Ry, Marguerite Koutsoukos, Cindy Gutzeit, I-Ting Teng, Tongqing Zhou, Dapeng Li, Barton F. Haynes, Peter D. Kwong, Adrian McDermott, Mark G. Lewis, Tong Ming Fu, Roman Chicz, Robbert van der Most, Kizzmekia S. Corbett, Mehul S. Suthar, Galit Alter, Mario Roederer, Nancy J. Sullivan, Daniel C. Douek, Barney S. Graham, Danilo Casimiro, Robert A. Seder
bioRxiv 2021.03.02.433390; doi: https://doi.org/10.1101/2021.03.02.433390
Vaccination with SARS-CoV-2 Spike Protein and AS03 Adjuvant Induces Rapid Anamnestic Antibodies in the Lung and Protects Against Virus Challenge in Nonhuman Primates
Joseph R. Francica, Barbara J. Flynn, Kathryn E. Foulds, Amy T. Noe, Anne P. Werner, Ian N. Moore, Matthew Gagne, Timothy S. Johnston, Courtney Tucker, Rachel L. Davis, Britta Flach, Sarah O’Connell, Shayne F. Andrew, Evan Lamb, Dillon R. Flebbe, Saule T. Nurmukhambetova, Mitzi M. Donaldson, John-Paul M. Todd, Alex Lee Zhu, Caroline Atyeo, Stephanie Fischinger, Matthew J Gorman, Sally Shin, Venkata Viswanadh Edara, Katharine Floyd, Lilin Lai, Alida Tylor, Elizabeth McCarthy, Valerie Lecouturier, Sophie Ruiz, Catherine Berry, Timothy Tibbitts, Hanne Andersen, Anthony Cook, Alan Dodson, Laurent Pessaint, Alex Van Ry, Marguerite Koutsoukos, Cindy Gutzeit, I-Ting Teng, Tongqing Zhou, Dapeng Li, Barton F. Haynes, Peter D. Kwong, Adrian McDermott, Mark G. Lewis, Tong Ming Fu, Roman Chicz, Robbert van der Most, Kizzmekia S. Corbett, Mehul S. Suthar, Galit Alter, Mario Roederer, Nancy J. Sullivan, Daniel C. Douek, Barney S. Graham, Danilo Casimiro, Robert A. Seder
bioRxiv 2021.03.02.433390; doi: https://doi.org/10.1101/2021.03.02.433390
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