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Reduced PTPRD expression differentially alters brain phosphotyrosine phosphoproteomic profiles of 2 and 12 month-old mice

View ORCID ProfileGeorge R Uhl, Ian M Henderson, Maria Martinez, Matthew P Stokes
doi: https://doi.org/10.1101/2021.03.02.433536
George R Uhl
1Biomedical Research Institute of New Mexico, Albuquerque New Mexico 87108 USA
2New Mexico VA Healthcare System, Albuquerque New Mexico 87108 USA
3Departments of Neurology, Neuroscience and Molecular Genetics and Microbiology, University of New Mexico, Albuquerque New Mexico 87106 USA
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  • For correspondence: George.Uhl@va.gov
Ian M Henderson
1Biomedical Research Institute of New Mexico, Albuquerque New Mexico 87108 USA
2New Mexico VA Healthcare System, Albuquerque New Mexico 87108 USA
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Maria Martinez
1Biomedical Research Institute of New Mexico, Albuquerque New Mexico 87108 USA
2New Mexico VA Healthcare System, Albuquerque New Mexico 87108 USA
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Matthew P Stokes
4Cell Signaling Technology, Inc, Danvers, Massachusetts 01923 USA
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Abstract

The receptor type protein tyrosine phosphatase PTPRD is implicated in maturation of synapses of expressing neurons, vulnerability to addictions, reward from addictive substances, vulnerability to restless leg syndrome and densities of neurofibrillary pathology in Alzheimer’s disease brains by a variety of evidence. However, PTPRD’s physiological substrates and adaptations to differences in levels of PTPRD expression in brains of young and aging animals have not been explored in depth. We report phosphoproteomic studies of brains of young and aged mice with different levels of PTPRD expression, gene ontology studies of genes identified in this way and validation of several candidate PTPRD substrates with in vitro assays using recombinant PTPRD phosphatase. PTPRD is well positioned to modulate the extent of phosphorylation of phosphotyrosine phosphoprotein substrates, including those involved in synaptic maturation and adaptation.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license.
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Posted March 02, 2021.
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Reduced PTPRD expression differentially alters brain phosphotyrosine phosphoproteomic profiles of 2 and 12 month-old mice
George R Uhl, Ian M Henderson, Maria Martinez, Matthew P Stokes
bioRxiv 2021.03.02.433536; doi: https://doi.org/10.1101/2021.03.02.433536
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Reduced PTPRD expression differentially alters brain phosphotyrosine phosphoproteomic profiles of 2 and 12 month-old mice
George R Uhl, Ian M Henderson, Maria Martinez, Matthew P Stokes
bioRxiv 2021.03.02.433536; doi: https://doi.org/10.1101/2021.03.02.433536

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