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Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice

Chih-Yun Lai, View ORCID ProfileAlbert To, Teri Ann S. Wong, Michael M. Lieberman, David E. Clements, James T. Senda, Aquena H. Ball, Laurent Pessaint, Hanne Andersen, Oreola Donini, Axel T. Lehrer
doi: https://doi.org/10.1101/2021.03.02.433614
Chih-Yun Lai
aDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA
bPacific Center for Emerging Infectious Disease Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA
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Albert To
aDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA
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  • ORCID record for Albert To
Teri Ann S. Wong
aDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA
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Michael M. Lieberman
aDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA
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David E. Clements
cHawaii Biotech, Inc., Honolulu, HI, USA
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James T. Senda
cHawaii Biotech, Inc., Honolulu, HI, USA
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Aquena H. Ball
aDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA
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Laurent Pessaint
dBioqual Inc., Rockville, MD, USA
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Hanne Andersen
dBioqual Inc., Rockville, MD, USA
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Oreola Donini
eSoligenix, Inc, Princetown, NJ, USA
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Axel T. Lehrer
aDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA
bPacific Center for Emerging Infectious Disease Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA
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  • For correspondence: lehrer@hawaii.edu
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Article Information

doi 
https://doi.org/10.1101/2021.03.02.433614
History 
  • March 3, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Chih-Yun Laia,b,1,
  2. Albert Toa,1,
  3. Teri Ann S. Wonga,
  4. Michael M. Liebermana,
  5. David E. Clementsc,
  6. James T. Sendac,
  7. Aquena H. Balla,
  8. Laurent Pessaintd,
  9. Hanne Andersend,
  10. Oreola Doninie and
  11. Axel T. Lehrera,b,*
  1. aDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA
  2. bPacific Center for Emerging Infectious Disease Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA
  3. cHawaii Biotech, Inc., Honolulu, HI, USA
  4. dBioqual Inc., Rockville, MD, USA
  5. eSoligenix, Inc, Princetown, NJ, USA
  1. ↵*Corresponding author at: University of Hawaii at Manoa, John A. Burns School of Medicine, Department of Tropical Medicine, 651 Ilalo Street, Honolulu, HI 96813, United States (Axel T. Lehrer: lehrer{at}hawaii.edu)
  1. ↵1 These authors contributed equally to this work

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Posted March 03, 2021.
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Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice
Chih-Yun Lai, Albert To, Teri Ann S. Wong, Michael M. Lieberman, David E. Clements, James T. Senda, Aquena H. Ball, Laurent Pessaint, Hanne Andersen, Oreola Donini, Axel T. Lehrer
bioRxiv 2021.03.02.433614; doi: https://doi.org/10.1101/2021.03.02.433614
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Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice
Chih-Yun Lai, Albert To, Teri Ann S. Wong, Michael M. Lieberman, David E. Clements, James T. Senda, Aquena H. Ball, Laurent Pessaint, Hanne Andersen, Oreola Donini, Axel T. Lehrer
bioRxiv 2021.03.02.433614; doi: https://doi.org/10.1101/2021.03.02.433614

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