Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice

Chih-Yun Lai; Albert To; Teri Ann S. Wong; Michael M. Lieberman; David E. Clements; James T. Senda; Aquena H. Ball; Laurent Pessaint; Hanne Andersen; Oreola Donini; Axel T. Lehrer

doi:10.1101/2021.03.02.433614

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Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice

Chih-Yun Lai, View ORCID ProfileAlbert To, Teri Ann S. Wong, Michael M. Lieberman, David E. Clements, James T. Senda, Aquena H. Ball, Laurent Pessaint, Hanne Andersen, Oreola Donini, Axel T. Lehrer

doi: https://doi.org/10.1101/2021.03.02.433614

Chih-Yun Lai

aDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA

bPacific Center for Emerging Infectious Disease Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA

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Albert To

aDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA

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ORCID record for Albert To

Teri Ann S. Wong

aDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA

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Michael M. Lieberman

aDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA

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David E. Clements

cHawaii Biotech, Inc., Honolulu, HI, USA

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James T. Senda

cHawaii Biotech, Inc., Honolulu, HI, USA

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Aquena H. Ball

aDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA

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Laurent Pessaint

dBioqual Inc., Rockville, MD, USA

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Hanne Andersen

dBioqual Inc., Rockville, MD, USA

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Oreola Donini

eSoligenix, Inc, Princetown, NJ, USA

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Axel T. Lehrer

aDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA

bPacific Center for Emerging Infectious Disease Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA

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For correspondence: lehrer@hawaii.edu

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Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice

Chih-Yun Lai, Albert To, Teri Ann S. Wong, Michael M. Lieberman, David E. Clements, James T. Senda, Aquena H. Ball, Laurent Pessaint, Hanne Andersen, Oreola Donini, Axel T. Lehrer

bioRxiv 2021.03.02.433614; doi: https://doi.org/10.1101/2021.03.02.433614

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Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice

Chih-Yun Lai, Albert To, Teri Ann S. Wong, Michael M. Lieberman, David E. Clements, James T. Senda, Aquena H. Ball, Laurent Pessaint, Hanne Andersen, Oreola Donini, Axel T. Lehrer

bioRxiv 2021.03.02.433614; doi: https://doi.org/10.1101/2021.03.02.433614

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