Confirmatory Results
Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans
Xiaofeng Dong, Rebekah Penrice-Randal, Hannah Goldswain, Tessa Prince, Nadine Randle, Javier Salguero, Julia Tree, Ecaterina Vamos, Charlotte Nelson, James P. Stewart, ISARIC4C Investigators, COVID-19 Genomics UK (COG-UK) Consortium, Malcolm G. Semple, View ORCID ProfileJ. Kenneth Baillie, Peter J. M. Openshaw, Lance Turtle, View ORCID ProfileDavid A. Matthews, Miles W. Carroll, Alistair C. Darby, Julian A. Hiscox
doi: https://doi.org/10.1101/2021.03.03.433753
Xiaofeng Dong
1Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
Rebekah Penrice-Randal
1Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
Hannah Goldswain
1Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
Tessa Prince
1Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
Nadine Randle
1Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
Javier Salguero
2Public Health England, Salisbury, UK
Julia Tree
2Public Health England, Salisbury, UK
Ecaterina Vamos
1Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
Charlotte Nelson
1Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
James P. Stewart
1Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
Malcolm G. Semple
1Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
3NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK
J. Kenneth Baillie
4The Roslin Institute, University of Edinburgh, UK
Peter J. M. Openshaw
5National Heart and Lung Institute, Imperial College London, UK
Lance Turtle
1Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
David A. Matthews
6University of Bristol, UK
Miles W. Carroll
2Public Health England, Salisbury, UK
Alistair C. Darby
1Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
Julian A. Hiscox
1Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
3NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK
7Infectious Diseases Horizontal Technology Centre (ID HTC), A*STAR, Singapore
Article usage
Posted March 05, 2021.
Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans
Xiaofeng Dong, Rebekah Penrice-Randal, Hannah Goldswain, Tessa Prince, Nadine Randle, Javier Salguero, Julia Tree, Ecaterina Vamos, Charlotte Nelson, James P. Stewart, ISARIC4C Investigators, COVID-19 Genomics UK (COG-UK) Consortium, Malcolm G. Semple, J. Kenneth Baillie, Peter J. M. Openshaw, Lance Turtle, David A. Matthews, Miles W. Carroll, Alistair C. Darby, Julian A. Hiscox
bioRxiv 2021.03.03.433753; doi: https://doi.org/10.1101/2021.03.03.433753
Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans
Xiaofeng Dong, Rebekah Penrice-Randal, Hannah Goldswain, Tessa Prince, Nadine Randle, Javier Salguero, Julia Tree, Ecaterina Vamos, Charlotte Nelson, James P. Stewart, ISARIC4C Investigators, COVID-19 Genomics UK (COG-UK) Consortium, Malcolm G. Semple, J. Kenneth Baillie, Peter J. M. Openshaw, Lance Turtle, David A. Matthews, Miles W. Carroll, Alistair C. Darby, Julian A. Hiscox
bioRxiv 2021.03.03.433753; doi: https://doi.org/10.1101/2021.03.03.433753
Subject Area
Subject Areas
- Biochemistry (11736)
- Bioengineering (8746)
- Bioinformatics (29186)
- Biophysics (14964)
- Cancer Biology (12084)
- Cell Biology (17401)
- Clinical Trials (138)
- Developmental Biology (9418)
- Ecology (14176)
- Epidemiology (2067)
- Evolutionary Biology (18299)
- Genetics (12235)
- Genomics (16793)
- Immunology (11863)
- Microbiology (28066)
- Molecular Biology (11580)
- Neuroscience (60925)
- Paleontology (451)
- Pathology (1870)
- Pharmacology and Toxicology (3238)
- Physiology (4956)
- Plant Biology (10422)
- Synthetic Biology (2883)
- Systems Biology (7338)
- Zoology (1650)