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Zoonotic spillover of SARS-CoV-2: mink-adapted virus in humans

View ORCID ProfileLukasz Rabalski, View ORCID ProfileMaciej Kosinski, View ORCID ProfileNatalia Mazur-Panasiuk, View ORCID ProfileBoguslaw Szewczyk, View ORCID ProfileKrystyna Bienkowska-Szewczyk, View ORCID ProfileRavi Kant, View ORCID ProfileTarja Sironen, View ORCID ProfileKrysztof Pyrć, View ORCID ProfileMaciej Grzybek
doi: https://doi.org/10.1101/2021.03.05.433713
Lukasz Rabalski
1Laboratory of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307, Gdansk, Poland
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Maciej Kosinski
1Laboratory of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307, Gdansk, Poland
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Natalia Mazur-Panasiuk
2Virogenetics Laboratory of Virology, Małopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7A, 30-387, Kraków, Poland
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Boguslaw Szewczyk
1Laboratory of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307, Gdansk, Poland
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Krystyna Bienkowska-Szewczyk
3Laboratory of Virus Molecular Biology, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307, Gdansk, Poland
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Ravi Kant
4Department of Virology, University of Helsinki, Haartmaninkatu 3, Helsinki FI-00290, Finland
5Department of Veterinary Biosciences, University of Helsinki, Agnes Sjöbergin katu 2, Helsinki FI-00790, Finland
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Tarja Sironen
4Department of Virology, University of Helsinki, Haartmaninkatu 3, Helsinki FI-00290, Finland
5Department of Veterinary Biosciences, University of Helsinki, Agnes Sjöbergin katu 2, Helsinki FI-00790, Finland
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Krysztof Pyrć
2Virogenetics Laboratory of Virology, Małopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7A, 30-387, Kraków, Poland
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  • For correspondence: ciej.grzybek{at}gumed.edu.pl k.a.pyrc{at}uj.edu.p
Maciej Grzybek
6Department of Tropical Parasitology, Institute of Maritime and Tropical Medicine, Medical University of Gdansk, Powstania Styczniowego 9B, 81-519, Gdynia, Poland
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  • For correspondence: ciej.grzybek{at}gumed.edu.pl k.a.pyrc{at}uj.edu.p
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ABSTRACT

The COVID-19 pandemic caused by SARS-CoV-2 started in fall 2019. A range of different mammalian species, including farmed mink, have been confirmed as susceptible to infection with this virus. We report here the spillover of mink-adapted SARS-CoV-2 from farmed mink to humans after extensive adaptation that lasted at least 3 months. We found the presence of four mutations in the S gene (that gave rise to variant: G75V, M177T, Y453F and C1247F) and others in an isolate obtained from SARS-CoV-2 positive patient.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Conflict of interest: None declared

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted March 05, 2021.
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Zoonotic spillover of SARS-CoV-2: mink-adapted virus in humans
Lukasz Rabalski, Maciej Kosinski, Natalia Mazur-Panasiuk, Boguslaw Szewczyk, Krystyna Bienkowska-Szewczyk, Ravi Kant, Tarja Sironen, Krysztof Pyrć, Maciej Grzybek
bioRxiv 2021.03.05.433713; doi: https://doi.org/10.1101/2021.03.05.433713
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Zoonotic spillover of SARS-CoV-2: mink-adapted virus in humans
Lukasz Rabalski, Maciej Kosinski, Natalia Mazur-Panasiuk, Boguslaw Szewczyk, Krystyna Bienkowska-Szewczyk, Ravi Kant, Tarja Sironen, Krysztof Pyrć, Maciej Grzybek
bioRxiv 2021.03.05.433713; doi: https://doi.org/10.1101/2021.03.05.433713

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