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Correlative light and electron microscopy reveals that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease
Ya Zhou, Thomas R. Peskett, Christian Landles, John B. Warner, Kirupa Sathasivam, Edward J. Smith, Shu Chen, Ronald Wetzel, Hilal A. Lashuel, Gillian P. Bates, Helen R. Saibil
doi: https://doi.org/10.1101/2021.03.05.433899
Ya Zhou
1Huntington’s Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London, UK
Thomas R. Peskett
2Institute of Structural and Molecular Biology, Birkbeck College, London, WC1E 7HX, UK
3Institute of Biochemistry, Department of Biology, ETH Zurich, Otto-Stern-Weg 3, 8093 Zurich, Switzerland
Christian Landles
1Huntington’s Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London, UK
John B. Warner
4Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérate de Lausanne (EPFL), Lausanne, Switzerland
Kirupa Sathasivam
1Huntington’s Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London, UK
Edward J. Smith
1Huntington’s Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London, UK
Shu Chen
2Institute of Structural and Molecular Biology, Birkbeck College, London, WC1E 7HX, UK
Ronald Wetzel
5Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
Hilal A. Lashuel
4Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérate de Lausanne (EPFL), Lausanne, Switzerland
Gillian P. Bates
1Huntington’s Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London, UK
Helen R. Saibil
2Institute of Structural and Molecular Biology, Birkbeck College, London, WC1E 7HX, UK
Posted March 05, 2021.
Correlative light and electron microscopy reveals that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease
Ya Zhou, Thomas R. Peskett, Christian Landles, John B. Warner, Kirupa Sathasivam, Edward J. Smith, Shu Chen, Ronald Wetzel, Hilal A. Lashuel, Gillian P. Bates, Helen R. Saibil
bioRxiv 2021.03.05.433899; doi: https://doi.org/10.1101/2021.03.05.433899
Correlative light and electron microscopy reveals that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease
Ya Zhou, Thomas R. Peskett, Christian Landles, John B. Warner, Kirupa Sathasivam, Edward J. Smith, Shu Chen, Ronald Wetzel, Hilal A. Lashuel, Gillian P. Bates, Helen R. Saibil
bioRxiv 2021.03.05.433899; doi: https://doi.org/10.1101/2021.03.05.433899
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