New Results
Within-sibship GWAS improve estimates of direct genetic effects
Laurence J Howe, Michel G Nivard, Tim T Morris, Ailin F Hansen, Humaira Rasheed, Yoonsu Cho, Geetha Chittoor, Penelope A Lind, Teemu Palviainen, Matthijs D van der Zee, Rosa Cheesman, Massimo Mangino, Yunzhang Wang, Shuai Li, Lucija Klaric, Scott M Ratliff, Lawrence F Bielak, Marianne Nygaard, Chandra A Reynolds, Jared V Balbona, Christopher R Bauer, Dorret I Boomsma, Aris Baras, Archie Campbell, Harry Campbell, Zhengming Chen, Paraskevi Christofidou, Christina C Dahm, Deepika R Dokuru, Luke M Evans, Eco JC de Geus, Sudheer Giddaluru, Scott D Gordon, K. Paige Harden, Alexandra Havdahl, W. David Hill, Shona M Kerr, Yongkang Kim, Hyeokmoon Kweon, Antti Latvala, Liming Li, Kuang Lin, Pekka Martikainen, Patrik KE Magnusson, Melinda C Mills, Deborah A Lawlor, John D Overton, Nancy L Pedersen, David J Porteous, Jeffrey Reid, Karri Silventoinen, Melissa C Southey, Travis T Mallard, Elliot M Tucker-Drob, Margaret J Wright, Social Science Genetic Association Consortium, Within Family Consortium, John K Hewitt, Matthew C Keller, Michael C Stallings, Kaare Christensen, Sharon LR Kardia, Patricia A Peyser, Jennifer A Smith, James F Wilson, John L Hopper, Sara Hägg, Tim D Spector, Jean-Baptiste Pingault, Robert Plomin, Meike Bartels, Nicholas G Martin, Anne E Justice, Iona Y Millwood, Kristian Hveem, Øyvind Naess, Cristen J Willer, Bjørn Olav Åsvold, Philipp D Koellinger, Jaakko Kaprio, Sarah E Medland, Robin G Walters, Daniel J Benjamin, Patrick Turley, David M Evans, George Davey Smith, Caroline Hayward, Ben Brumpton, Gibran Hemani, Neil M Davies
doi: https://doi.org/10.1101/2021.03.05.433935
Laurence J Howe
1Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
2Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Michel G Nivard
3Department of Biological Psychology, Netherlands Twin Registry, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands
Tim T Morris
1Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
2Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Ailin F Hansen
4K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway
Humaira Rasheed
4K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway
Yoonsu Cho
1Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
2Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Geetha Chittoor
5Department of Population Health Sciences, Geisinger Health, 100 N. Academy Ave., Danville, PA 17822
Penelope A Lind
6Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia
7School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia
8Faculty of Medicine, University of Queensland, Brisbane, Australia
Teemu Palviainen
9Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland
Matthijs D van der Zee
3Department of Biological Psychology, Netherlands Twin Registry, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands
Rosa Cheesman
10PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway
11Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Massimo Mangino
12Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK
13NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust, London SE1 9RT, UK
Yunzhang Wang
14Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Shuai Li
15Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia
16Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
17Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia
Lucija Klaric
18MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland
Scott M Ratliff
19Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Lawrence F Bielak
19Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Marianne Nygaard
20The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark
21Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
Chandra A Reynolds
22Department of Psychology, University of California – Riverside, Riverside, CA, USA
Jared V Balbona
23Department of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, 80309
24Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, 80309
Christopher R Bauer
25BioMarin Pharmaceutical, Novato, CA
26Biomedical and Translational Informatics, Geisinger Health, 100 N. Academy Ave., Danville, PA 17822
Dorret I Boomsma
3Department of Biological Psychology, Netherlands Twin Registry, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands
27Amsterdam Public Health (APH) and Amsterdam Reproduction and Development (AR&D)
Aris Baras
28Regeneron Genetics Center, Tarrytown, NY, USA
Archie Campbell
29Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh
Harry Campbell
30Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland
Zhengming Chen
31Nuffield Department of Population Health, University of Oxford, Oxford, UK
32MRC Population Health Research Unit, University of Oxford, Oxford, UK
Paraskevi Christofidou
12Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK
Christina C Dahm
33Department of Public Health, Aarhus University, Bartholins Alle 2, 8000 Aarhus, Denmark
Deepika R Dokuru
23Department of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, 80309
24Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, 80309
Luke M Evans
24Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, 80309
34Department of Ecology & Evolutionary Biology, University of Colorado at Boulder, Boulder, CO, 80309
Eco JC de Geus
3Department of Biological Psychology, Netherlands Twin Registry, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands
35Amsterdam Public Health research institute, Amsterdam UMC, The Netherlands
Sudheer Giddaluru
36Institute of Health and Society, University of Oslo
37Norwegian Institute of Public Health
Scott D Gordon
38Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia
K. Paige Harden
39Department of Psychology and Population Research Center, University of Texas at Austin
Alexandra Havdahl
40Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway
41Deparment of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway
W. David Hill
42Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
43Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
Shona M Kerr
18MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland
Yongkang Kim
24Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, 80309
Hyeokmoon Kweon
44Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, De Boelelaan 1105, 1081 HV Amsterdam, The Netherlands
Antti Latvala
9Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland
45Institute of Criminology and Legal Policy, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland
Liming Li
46Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China
Kuang Lin
31Nuffield Department of Population Health, University of Oxford, Oxford, UK
Pekka Martikainen
47Population Research Unit, Faculty of Social Sciences, University of Helsinki, P.O. Box 18 (Unioninkatu 35), FIN-00014 University of Helsinki, Finland
48The Max Planck Institute for Demographic Research, Germany
49Department of Public Health Sciences, Stockholm University, Sweden
Patrik KE Magnusson
14Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Melinda C Mills
50Leverhulme Centre for Demographic Science, University of Oxford, Oxford OX1 1JD
Deborah A Lawlor
1Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
2Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
51Bristol NIHR Biomedical Research Centre, UK
John D Overton
27Amsterdam Public Health (APH) and Amsterdam Reproduction and Development (AR&D)
Nancy L Pedersen
14Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
David J Porteous
25BioMarin Pharmaceutical, Novato, CA
Jeffrey Reid
28Regeneron Genetics Center, Tarrytown, NY, USA
Karri Silventoinen
47Population Research Unit, Faculty of Social Sciences, University of Helsinki, P.O. Box 18 (Unioninkatu 35), FIN-00014 University of Helsinki, Finland
Melissa C Southey
17Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia
52Department of Clinical Pathology, Melbourne Medicial School, The University of Melbourne, VIC, 3010, Australia
53Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia
Travis T Mallard
39Department of Psychology and Population Research Center, University of Texas at Austin
Elliot M Tucker-Drob
39Department of Psychology and Population Research Center, University of Texas at Austin
Margaret J Wright
54Queensland Brain Institute, The University of Queensland, Brisbane, Australia
John K Hewitt
23Department of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, 80309
24Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, 80309
Matthew C Keller
23Department of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, 80309
24Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, 80309
Michael C Stallings
23Department of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, 80309
24Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, 80309
Kaare Christensen
20The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark
21Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
55Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
Sharon LR Kardia
19Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Patricia A Peyser
19Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Jennifer A Smith
19Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
56Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA
James F Wilson
18MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland
30Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland
John L Hopper
15Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia
Sara Hägg
14Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Tim D Spector
12Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK
Jean-Baptiste Pingault
11Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
57Department of Clinical, Educational and Health Psychology, University College London, London, UK
Robert Plomin
11Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Meike Bartels
3Department of Biological Psychology, Netherlands Twin Registry, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands
Nicholas G Martin
38Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia
Anne E Justice
5Department of Population Health Sciences, Geisinger Health, 100 N. Academy Ave., Danville, PA 17822
Iona Y Millwood
31Nuffield Department of Population Health, University of Oxford, Oxford, UK
32MRC Population Health Research Unit, University of Oxford, Oxford, UK
Kristian Hveem
4K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway
58HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway
Øyvind Naess
36Institute of Health and Society, University of Oslo
37Norwegian Institute of Public Health
Cristen J Willer
4K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway
59Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA
60Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA
Bjørn Olav Åsvold
4K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway
58HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway
61Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
Philipp D Koellinger
44Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, De Boelelaan 1105, 1081 HV Amsterdam, The Netherlands
62La Follette School of Public Affairs, University of Wisconsin-Madison, 1225 Observatory Drive, Madison, WI 53706, USA
Jaakko Kaprio
9Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland
Sarah E Medland
6Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia
8Faculty of Medicine, University of Queensland, Brisbane, Australia
63School of Psychology, University of Queensland, Brisbane, Australia
Robin G Walters
31Nuffield Department of Population Health, University of Oxford, Oxford, UK
32MRC Population Health Research Unit, University of Oxford, Oxford, UK
Daniel J Benjamin
64UCLA Anderson School of Management 110 Westwood Plaza Entrepreneurs Hall, Suite C515 Los Angeles, CA 90095-1481, USA
65Human Genetics Department, UCLA David Geffen School of Medicine, Gonda (Goldschmied) Neuroscience and Genetics Research Center, 695 Charles E. Young Drive South, Box 708822, Los Angeles, CA 90095-7088, USA
66National Bureau of Economic Research, 1050 Massachusetts Ave, Cambridge, MA 02138, USA
Patrick Turley
67Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA
68Department of Economics, University of Southern California, Los Angeles, California, USA
David M Evans
1Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
69University of Queensland Diamantina Institute, University of Queensland, Brisbane, 4102, Australia
George Davey Smith
1Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
2Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Caroline Hayward
18MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland
Ben Brumpton
1Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
4K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway
58HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway
Gibran Hemani
1Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
2Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Neil M Davies
1Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
2Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
4K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway
Posted March 07, 2021.
Within-sibship GWAS improve estimates of direct genetic effects
Laurence J Howe, Michel G Nivard, Tim T Morris, Ailin F Hansen, Humaira Rasheed, Yoonsu Cho, Geetha Chittoor, Penelope A Lind, Teemu Palviainen, Matthijs D van der Zee, Rosa Cheesman, Massimo Mangino, Yunzhang Wang, Shuai Li, Lucija Klaric, Scott M Ratliff, Lawrence F Bielak, Marianne Nygaard, Chandra A Reynolds, Jared V Balbona, Christopher R Bauer, Dorret I Boomsma, Aris Baras, Archie Campbell, Harry Campbell, Zhengming Chen, Paraskevi Christofidou, Christina C Dahm, Deepika R Dokuru, Luke M Evans, Eco JC de Geus, Sudheer Giddaluru, Scott D Gordon, K. Paige Harden, Alexandra Havdahl, W. David Hill, Shona M Kerr, Yongkang Kim, Hyeokmoon Kweon, Antti Latvala, Liming Li, Kuang Lin, Pekka Martikainen, Patrik KE Magnusson, Melinda C Mills, Deborah A Lawlor, John D Overton, Nancy L Pedersen, David J Porteous, Jeffrey Reid, Karri Silventoinen, Melissa C Southey, Travis T Mallard, Elliot M Tucker-Drob, Margaret J Wright, Social Science Genetic Association Consortium, Within Family Consortium, John K Hewitt, Matthew C Keller, Michael C Stallings, Kaare Christensen, Sharon LR Kardia, Patricia A Peyser, Jennifer A Smith, James F Wilson, John L Hopper, Sara Hägg, Tim D Spector, Jean-Baptiste Pingault, Robert Plomin, Meike Bartels, Nicholas G Martin, Anne E Justice, Iona Y Millwood, Kristian Hveem, Øyvind Naess, Cristen J Willer, Bjørn Olav Åsvold, Philipp D Koellinger, Jaakko Kaprio, Sarah E Medland, Robin G Walters, Daniel J Benjamin, Patrick Turley, David M Evans, George Davey Smith, Caroline Hayward, Ben Brumpton, Gibran Hemani, Neil M Davies
bioRxiv 2021.03.05.433935; doi: https://doi.org/10.1101/2021.03.05.433935
Within-sibship GWAS improve estimates of direct genetic effects
Laurence J Howe, Michel G Nivard, Tim T Morris, Ailin F Hansen, Humaira Rasheed, Yoonsu Cho, Geetha Chittoor, Penelope A Lind, Teemu Palviainen, Matthijs D van der Zee, Rosa Cheesman, Massimo Mangino, Yunzhang Wang, Shuai Li, Lucija Klaric, Scott M Ratliff, Lawrence F Bielak, Marianne Nygaard, Chandra A Reynolds, Jared V Balbona, Christopher R Bauer, Dorret I Boomsma, Aris Baras, Archie Campbell, Harry Campbell, Zhengming Chen, Paraskevi Christofidou, Christina C Dahm, Deepika R Dokuru, Luke M Evans, Eco JC de Geus, Sudheer Giddaluru, Scott D Gordon, K. Paige Harden, Alexandra Havdahl, W. David Hill, Shona M Kerr, Yongkang Kim, Hyeokmoon Kweon, Antti Latvala, Liming Li, Kuang Lin, Pekka Martikainen, Patrik KE Magnusson, Melinda C Mills, Deborah A Lawlor, John D Overton, Nancy L Pedersen, David J Porteous, Jeffrey Reid, Karri Silventoinen, Melissa C Southey, Travis T Mallard, Elliot M Tucker-Drob, Margaret J Wright, Social Science Genetic Association Consortium, Within Family Consortium, John K Hewitt, Matthew C Keller, Michael C Stallings, Kaare Christensen, Sharon LR Kardia, Patricia A Peyser, Jennifer A Smith, James F Wilson, John L Hopper, Sara Hägg, Tim D Spector, Jean-Baptiste Pingault, Robert Plomin, Meike Bartels, Nicholas G Martin, Anne E Justice, Iona Y Millwood, Kristian Hveem, Øyvind Naess, Cristen J Willer, Bjørn Olav Åsvold, Philipp D Koellinger, Jaakko Kaprio, Sarah E Medland, Robin G Walters, Daniel J Benjamin, Patrick Turley, David M Evans, George Davey Smith, Caroline Hayward, Ben Brumpton, Gibran Hemani, Neil M Davies
bioRxiv 2021.03.05.433935; doi: https://doi.org/10.1101/2021.03.05.433935
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