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Gait-phase modulates alpha and beta oscillations in the pedunculopontine nucleus

Shenghong He, Alceste Deli, Petra Fischer, Christoph Wiest, Yongzhi Huang, Sean Martin, Saed Khawaldeh, Tipu Z. Aziz, Alexander L Green, Peter Brown, Huiling Tan
doi: https://doi.org/10.1101/2021.03.05.434086
Shenghong He
1MRC Brain Network Dynamics Unit at the University of Oxford, United Kingdom
2Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
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Alceste Deli
3Nuffield Department of Surgical Sciences, University of Oxford, United Kingdom
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Petra Fischer
1MRC Brain Network Dynamics Unit at the University of Oxford, United Kingdom
2Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
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Christoph Wiest
1MRC Brain Network Dynamics Unit at the University of Oxford, United Kingdom
2Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
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Yongzhi Huang
4Academy of Medical Engineering and Translational Medicine, Tianjin University, China
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Sean Martin
3Nuffield Department of Surgical Sciences, University of Oxford, United Kingdom
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Saed Khawaldeh
1MRC Brain Network Dynamics Unit at the University of Oxford, United Kingdom
2Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
5Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, United Kingdom
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Tipu Z. Aziz
2Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
3Nuffield Department of Surgical Sciences, University of Oxford, United Kingdom
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Alexander L Green
2Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
3Nuffield Department of Surgical Sciences, University of Oxford, United Kingdom
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Peter Brown
1MRC Brain Network Dynamics Unit at the University of Oxford, United Kingdom
2Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
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Huiling Tan
1MRC Brain Network Dynamics Unit at the University of Oxford, United Kingdom
2Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
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  • For correspondence: huiling.tan@ndcn.ox.ac.uk
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Abstract

Backgroud The pedunculopontine nucleus (PPN) is a reticular collection of neurons at the junction of the midbrain and pons, playing an important role in modulating posture and locomotion. Deep brain stimulation of the PPN has been proposed as an emerging treatment for patients with Parkinson’s disease (PD) or multiple system atrophy (MSA) suffering gait-related atypical parkinsonian syndromes.

Objective In this study, we investigated PPN activities during gait to better understand its functional role in locomotion. Specifically, we investigated whether PPN activity is rhythmically modulated during locomotion.

Methods PPN local field potential (LFP) activities were recorded from PD or MSA patients suffering from gait difficulties during stepping in place or free walking. Simultaneous measurements from force plates or accelerometers were used to determine the phase within each gait cycle at each time point.

Results Our results showed that activities in the alpha and beta frequency bands in the PPN LFPs were rhythmically modulated by the gait phase within gait cycles, with a higher modulation index when the stepping rhythm was more regular. Meanwhile, the PPN-cortical coherence was most prominent in the alpha band. Both gait-phase related modulation in the alpha/beta power and the PPN-cortical coherence in the alpha frequency band were spatially specific to the PPN and did not extend to surrounding regions.

Conclusions These results raise the possibility that alternating PPN stimulation in tandem with the gait rhythm may be more beneficial for gait control than continuous stimulation, although this remains to be established in future studies.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Relevant conflicts of interests/financial disclosures P.B is a consultant for Medtronic. None of the other authors have conflicts of interest to report.

  • Funding This work was supported by the MRC (MR/P012272/1 and MC_UU_00003/2), the National Institute for Health Research (Oxford Biomedical Research Centre), and the Rosetrees Trust.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 07, 2021.
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Gait-phase modulates alpha and beta oscillations in the pedunculopontine nucleus
Shenghong He, Alceste Deli, Petra Fischer, Christoph Wiest, Yongzhi Huang, Sean Martin, Saed Khawaldeh, Tipu Z. Aziz, Alexander L Green, Peter Brown, Huiling Tan
bioRxiv 2021.03.05.434086; doi: https://doi.org/10.1101/2021.03.05.434086
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Gait-phase modulates alpha and beta oscillations in the pedunculopontine nucleus
Shenghong He, Alceste Deli, Petra Fischer, Christoph Wiest, Yongzhi Huang, Sean Martin, Saed Khawaldeh, Tipu Z. Aziz, Alexander L Green, Peter Brown, Huiling Tan
bioRxiv 2021.03.05.434086; doi: https://doi.org/10.1101/2021.03.05.434086

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