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BCOR and BCORL1 mutations disrupt PRC1.1 repressive function in leukemia by unlinking the RING-PCGF1 enzymatic core from target genes
Eva J. Schaefer, Helen C. Wang, Clifford A. Meyer, Paloma Cejas, Micah D. Gearhart, Emmalee R. Adelman, Iman Fares, Annie Apffel, Klothilda Lim, Yingtian Xie, Christopher J. Gibson, Monica Schenone, H. Moses Murdock, Eunice S. Wang, Lukasz P. Gondek, View ORCID ProfileMartin P. Carroll, Rahul S. Vedula, Eric S. Winer, Jacqueline S. Garcia, Richard M. Stone, Marlise R. Luskin, Steven A. Carr, View ORCID ProfileHenry W. Long, Vivian J. Bardwell, Maria E. Figueroa, R. Coleman Lindsley
doi: https://doi.org/10.1101/2021.03.08.433705
Eva J. Schaefer
1Department of Medical Oncology, Division of Hematologic Neoplasia, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Helen C. Wang
1Department of Medical Oncology, Division of Hematologic Neoplasia, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Clifford A. Meyer
2Department of Data Science, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA
Paloma Cejas
3Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Micah D. Gearhart
4Developmental Biology Center, Masonic Cancer Center, and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
Emmalee R. Adelman
5Sylvester Comprehensive Cancer Center, Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
6Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
Iman Fares
1Department of Medical Oncology, Division of Hematologic Neoplasia, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Annie Apffel
7Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Klothilda Lim
3Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Yingtian Xie
3Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Christopher J. Gibson
1Department of Medical Oncology, Division of Hematologic Neoplasia, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Monica Schenone
7Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
H. Moses Murdock
1Department of Medical Oncology, Division of Hematologic Neoplasia, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Eunice S. Wang
8Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA
Lukasz P. Gondek
9Division of Molecular Pathology, Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA
Martin P. Carroll
10Department of Medicine, Perelman Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
Rahul S. Vedula
1Department of Medical Oncology, Division of Hematologic Neoplasia, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Eric S. Winer
1Department of Medical Oncology, Division of Hematologic Neoplasia, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Jacqueline S. Garcia
1Department of Medical Oncology, Division of Hematologic Neoplasia, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Richard M. Stone
1Department of Medical Oncology, Division of Hematologic Neoplasia, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Marlise R. Luskin
1Department of Medical Oncology, Division of Hematologic Neoplasia, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Steven A. Carr
7Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Henry W. Long
3Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Vivian J. Bardwell
4Developmental Biology Center, Masonic Cancer Center, and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
Maria E. Figueroa
5Sylvester Comprehensive Cancer Center, Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
R. Coleman Lindsley
1Department of Medical Oncology, Division of Hematologic Neoplasia, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Article usage
Posted March 08, 2021.
BCOR and BCORL1 mutations disrupt PRC1.1 repressive function in leukemia by unlinking the RING-PCGF1 enzymatic core from target genes
Eva J. Schaefer, Helen C. Wang, Clifford A. Meyer, Paloma Cejas, Micah D. Gearhart, Emmalee R. Adelman, Iman Fares, Annie Apffel, Klothilda Lim, Yingtian Xie, Christopher J. Gibson, Monica Schenone, H. Moses Murdock, Eunice S. Wang, Lukasz P. Gondek, Martin P. Carroll, Rahul S. Vedula, Eric S. Winer, Jacqueline S. Garcia, Richard M. Stone, Marlise R. Luskin, Steven A. Carr, Henry W. Long, Vivian J. Bardwell, Maria E. Figueroa, R. Coleman Lindsley
bioRxiv 2021.03.08.433705; doi: https://doi.org/10.1101/2021.03.08.433705
BCOR and BCORL1 mutations disrupt PRC1.1 repressive function in leukemia by unlinking the RING-PCGF1 enzymatic core from target genes
Eva J. Schaefer, Helen C. Wang, Clifford A. Meyer, Paloma Cejas, Micah D. Gearhart, Emmalee R. Adelman, Iman Fares, Annie Apffel, Klothilda Lim, Yingtian Xie, Christopher J. Gibson, Monica Schenone, H. Moses Murdock, Eunice S. Wang, Lukasz P. Gondek, Martin P. Carroll, Rahul S. Vedula, Eric S. Winer, Jacqueline S. Garcia, Richard M. Stone, Marlise R. Luskin, Steven A. Carr, Henry W. Long, Vivian J. Bardwell, Maria E. Figueroa, R. Coleman Lindsley
bioRxiv 2021.03.08.433705; doi: https://doi.org/10.1101/2021.03.08.433705
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