Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Control of Parallel Hippocampal Output Pathways by Amygdalar Long-Range Inhibition

View ORCID ProfileRawan AlSubaie, View ORCID ProfileRyan W S Wee, Anne Ritoux, View ORCID ProfileKaryna Mischanchuk, View ORCID ProfileDaniel Regester, View ORCID ProfileAndrew F MacAskill
doi: https://doi.org/10.1101/2021.03.08.434367
Rawan AlSubaie
1Department of Neuroscience, Physiology and Pharmacology, University College London, Gower St, London, WC1E 6BT
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Rawan AlSubaie
Ryan W S Wee
1Department of Neuroscience, Physiology and Pharmacology, University College London, Gower St, London, WC1E 6BT
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ryan W S Wee
Anne Ritoux
1Department of Neuroscience, Physiology and Pharmacology, University College London, Gower St, London, WC1E 6BT
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Karyna Mischanchuk
1Department of Neuroscience, Physiology and Pharmacology, University College London, Gower St, London, WC1E 6BT
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Karyna Mischanchuk
Daniel Regester
1Department of Neuroscience, Physiology and Pharmacology, University College London, Gower St, London, WC1E 6BT
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Daniel Regester
Andrew F MacAskill
1Department of Neuroscience, Physiology and Pharmacology, University College London, Gower St, London, WC1E 6BT
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Andrew F MacAskill
  • For correspondence: a.macaskill@ucl.ac.uk
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

ABSTRACT

Projections from the basal amygdala (BA) to the ventral hippocampus (vH) are proposed to provide information about the rewarding or threatening nature of learned associations to support appropriate goal-directed and anxiety-like behaviour. Such behaviour occurs via the differential activity of multiple, parallel populations of pyramidal neurons in vH that project to distinct downstream targets, but the nature of BA input and how it connects with these populations is unclear. Using channelrhodopsin-2-assisted circuit mapping in mice, we show that BA input to vH consists of both excitatory and inhibitory projections. Excitatory input specifically targets BA- and nucleus accumbens-projecting vH neurons, and avoids prefrontal cortex-projecting vH neurons; while inhibitory input preferentially targets BA-projecting neurons. Through this specific connectivity, BA inhibitory projections gate place-value associations by controlling the activity of nucleus accumbens-projecting vH neurons. Our results define a parallel excitatory and inhibitory projection from BA to vH that can support goal-directed behaviour.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted March 08, 2021.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Control of Parallel Hippocampal Output Pathways by Amygdalar Long-Range Inhibition
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Control of Parallel Hippocampal Output Pathways by Amygdalar Long-Range Inhibition
Rawan AlSubaie, Ryan W S Wee, Anne Ritoux, Karyna Mischanchuk, Daniel Regester, Andrew F MacAskill
bioRxiv 2021.03.08.434367; doi: https://doi.org/10.1101/2021.03.08.434367
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Control of Parallel Hippocampal Output Pathways by Amygdalar Long-Range Inhibition
Rawan AlSubaie, Ryan W S Wee, Anne Ritoux, Karyna Mischanchuk, Daniel Regester, Andrew F MacAskill
bioRxiv 2021.03.08.434367; doi: https://doi.org/10.1101/2021.03.08.434367

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4237)
  • Biochemistry (9155)
  • Bioengineering (6797)
  • Bioinformatics (24052)
  • Biophysics (12149)
  • Cancer Biology (9562)
  • Cell Biology (13814)
  • Clinical Trials (138)
  • Developmental Biology (7653)
  • Ecology (11729)
  • Epidemiology (2066)
  • Evolutionary Biology (15534)
  • Genetics (10663)
  • Genomics (14346)
  • Immunology (9503)
  • Microbiology (22876)
  • Molecular Biology (9113)
  • Neuroscience (49080)
  • Paleontology (357)
  • Pathology (1487)
  • Pharmacology and Toxicology (2576)
  • Physiology (3851)
  • Plant Biology (8347)
  • Scientific Communication and Education (1473)
  • Synthetic Biology (2299)
  • Systems Biology (6202)
  • Zoology (1302)