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The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

Andrea L. Cathcart, Colin Havenar-Daughton, Florian A. Lempp, Daphne Ma, Michael A. Schmid, Maria L. Agostini, Barbara Guarino, Julia Di iulio, Laura E. Rosen, Heather Tucker, Joshua Dillen, Sambhavi Subramanian, Barbara Sloan, Siro Bianchi, Dora Pinto, Christian Saliba, Jason A Wojcechowskyj, Julia Noack, Jiayi Zhou, Hannah Kaiser, Arthur Chase, Martin Montiel-Ruiz, Exequiel Dellota Jr., Arnold Park, Roberto Spreafico, Anna Sahakyan, Elvin J. Lauron, Nadine Czudnochowski, Elisabetta Cameroni, Sarah Ledoux, Adam Werts, Christophe Colas, Leah Soriaga, Amalio Telenti, Lisa A. Purcell, Seungmin Hwang, Gyorgy Snell, Herbert W. Virgin, Davide Corti, Christy M. Hebner
doi: https://doi.org/10.1101/2021.03.09.434607
Andrea L. Cathcart
1Vir Biotechnology, San Francisco, California 94158, USA
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Colin Havenar-Daughton
1Vir Biotechnology, San Francisco, California 94158, USA
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Florian A. Lempp
1Vir Biotechnology, San Francisco, California 94158, USA
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Daphne Ma
1Vir Biotechnology, San Francisco, California 94158, USA
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Michael A. Schmid
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
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Maria L. Agostini
1Vir Biotechnology, San Francisco, California 94158, USA
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Barbara Guarino
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
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Julia Di iulio
1Vir Biotechnology, San Francisco, California 94158, USA
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Laura E. Rosen
1Vir Biotechnology, San Francisco, California 94158, USA
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Heather Tucker
1Vir Biotechnology, San Francisco, California 94158, USA
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Joshua Dillen
1Vir Biotechnology, San Francisco, California 94158, USA
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Sambhavi Subramanian
1Vir Biotechnology, San Francisco, California 94158, USA
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Barbara Sloan
1Vir Biotechnology, San Francisco, California 94158, USA
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Siro Bianchi
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
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Dora Pinto
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
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Christian Saliba
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
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Jason A Wojcechowskyj
1Vir Biotechnology, San Francisco, California 94158, USA
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Julia Noack
1Vir Biotechnology, San Francisco, California 94158, USA
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Jiayi Zhou
1Vir Biotechnology, San Francisco, California 94158, USA
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Hannah Kaiser
1Vir Biotechnology, San Francisco, California 94158, USA
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Arthur Chase
1Vir Biotechnology, San Francisco, California 94158, USA
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Martin Montiel-Ruiz
1Vir Biotechnology, San Francisco, California 94158, USA
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Exequiel Dellota Jr.
1Vir Biotechnology, San Francisco, California 94158, USA
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Arnold Park
1Vir Biotechnology, San Francisco, California 94158, USA
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Roberto Spreafico
1Vir Biotechnology, San Francisco, California 94158, USA
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Anna Sahakyan
1Vir Biotechnology, San Francisco, California 94158, USA
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Elvin J. Lauron
1Vir Biotechnology, San Francisco, California 94158, USA
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Nadine Czudnochowski
1Vir Biotechnology, San Francisco, California 94158, USA
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Elisabetta Cameroni
1Vir Biotechnology, San Francisco, California 94158, USA
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Sarah Ledoux
1Vir Biotechnology, San Francisco, California 94158, USA
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Adam Werts
3Lovelace Biomedical, Albuquerque, New Mexico 87108, USA
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Christophe Colas
1Vir Biotechnology, San Francisco, California 94158, USA
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Leah Soriaga
1Vir Biotechnology, San Francisco, California 94158, USA
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Amalio Telenti
1Vir Biotechnology, San Francisco, California 94158, USA
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Lisa A. Purcell
1Vir Biotechnology, San Francisco, California 94158, USA
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Seungmin Hwang
1Vir Biotechnology, San Francisco, California 94158, USA
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Gyorgy Snell
1Vir Biotechnology, San Francisco, California 94158, USA
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Herbert W. Virgin
1Vir Biotechnology, San Francisco, California 94158, USA
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Davide Corti
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
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Christy M. Hebner
1Vir Biotechnology, San Francisco, California 94158, USA
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  • For correspondence: chebner@vir.bio
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Article Information

doi 
https://doi.org/10.1101/2021.03.09.434607
History 
  • December 1, 2021.

Article Versions

  • Version 1 (March 10, 2021 - 18:30).
  • Version 2 (May 11, 2021 - 10:25).
  • Version 3 (May 13, 2021 - 08:01).
  • Version 4 (June 24, 2021 - 12:16).
  • Version 5 (July 26, 2021 - 10:28).
  • Version 6 (August 6, 2021 - 15:49).
  • Version 7 (September 30, 2021 - 09:44).
  • You are currently viewing Version 8 of this article (December 1, 2021 - 21:27).
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Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Andrea L. Cathcart1,
  2. Colin Havenar-Daughton1,
  3. Florian A. Lempp1,
  4. Daphne Ma1,
  5. Michael A. Schmid2,
  6. Maria L. Agostini1,
  7. Barbara Guarino2,
  8. Julia Di iulio1,
  9. Laura E. Rosen1,
  10. Heather Tucker1,
  11. Joshua Dillen1,
  12. Sambhavi Subramanian1,
  13. Barbara Sloan1,
  14. Siro Bianchi2,
  15. Dora Pinto2,
  16. Christian Saliba2,
  17. Jason A Wojcechowskyj1,
  18. Julia Noack1,
  19. Jiayi Zhou1,
  20. Hannah Kaiser1,
  21. Arthur Chase1,
  22. Martin Montiel-Ruiz1,
  23. Exequiel Dellota Jr.1,
  24. Arnold Park1,
  25. Roberto Spreafico1,
  26. Anna Sahakyan1,
  27. Elvin J. Lauron1,
  28. Nadine Czudnochowski1,
  29. Elisabetta Cameroni1,
  30. Sarah Ledoux1,
  31. Adam Werts3,
  32. Christophe Colas1,
  33. Leah Soriaga1,
  34. Amalio Telenti1,
  35. Lisa A. Purcell1,
  36. Seungmin Hwang1,
  37. Gyorgy Snell1,
  38. Herbert W. Virgin1,
  39. Davide Corti2 and
  40. Christy M. Hebner1,*
  1. 1Vir Biotechnology, San Francisco, California 94158, USA
  2. 2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
  3. 3Lovelace Biomedical, Albuquerque, New Mexico 87108, USA
  1. ↵*corresponding author: chebner{at}vir.bio
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The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2
Andrea L. Cathcart, Colin Havenar-Daughton, Florian A. Lempp, Daphne Ma, Michael A. Schmid, Maria L. Agostini, Barbara Guarino, Julia Di iulio, Laura E. Rosen, Heather Tucker, Joshua Dillen, Sambhavi Subramanian, Barbara Sloan, Siro Bianchi, Dora Pinto, Christian Saliba, Jason A Wojcechowskyj, Julia Noack, Jiayi Zhou, Hannah Kaiser, Arthur Chase, Martin Montiel-Ruiz, Exequiel Dellota Jr., Arnold Park, Roberto Spreafico, Anna Sahakyan, Elvin J. Lauron, Nadine Czudnochowski, Elisabetta Cameroni, Sarah Ledoux, Adam Werts, Christophe Colas, Leah Soriaga, Amalio Telenti, Lisa A. Purcell, Seungmin Hwang, Gyorgy Snell, Herbert W. Virgin, Davide Corti, Christy M. Hebner
bioRxiv 2021.03.09.434607; doi: https://doi.org/10.1101/2021.03.09.434607
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The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2
Andrea L. Cathcart, Colin Havenar-Daughton, Florian A. Lempp, Daphne Ma, Michael A. Schmid, Maria L. Agostini, Barbara Guarino, Julia Di iulio, Laura E. Rosen, Heather Tucker, Joshua Dillen, Sambhavi Subramanian, Barbara Sloan, Siro Bianchi, Dora Pinto, Christian Saliba, Jason A Wojcechowskyj, Julia Noack, Jiayi Zhou, Hannah Kaiser, Arthur Chase, Martin Montiel-Ruiz, Exequiel Dellota Jr., Arnold Park, Roberto Spreafico, Anna Sahakyan, Elvin J. Lauron, Nadine Czudnochowski, Elisabetta Cameroni, Sarah Ledoux, Adam Werts, Christophe Colas, Leah Soriaga, Amalio Telenti, Lisa A. Purcell, Seungmin Hwang, Gyorgy Snell, Herbert W. Virgin, Davide Corti, Christy M. Hebner
bioRxiv 2021.03.09.434607; doi: https://doi.org/10.1101/2021.03.09.434607

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