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Bromodomain and extraterminal protein inhibitor, apabetalone (RVX-208), reduces ACE2 expression and attenuates SARS-CoV-2 infection in vitro
Dean Gilham, Audrey L Smith, Li Fu, Dalia Y Moore, Abenaya Muralidharan, St. Patrick M Reid, Stephanie C Stotz, Jan O Johansson, Michael Sweeney, Norman CW Wong, Ewelina Kulikowski, Dalia El-Gamal
doi: https://doi.org/10.1101/2021.03.10.432949
Dean Gilham
aResverlogix Corp., 300, 4820 Richard Road SW, Calgary, Alberta, Canada, T3E 6L1
Audrey L Smith
bEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 NE Med Center, BCC 4.12.396, Omaha, Nebraska, USA 68198
Li Fu
aResverlogix Corp., 300, 4820 Richard Road SW, Calgary, Alberta, Canada, T3E 6L1
Dalia Y Moore
bEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 NE Med Center, BCC 4.12.396, Omaha, Nebraska, USA 68198
Abenaya Muralidharan
cDepartment of Pathology and Microbiology, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, Nebraska, USA 68198
St. Patrick M Reid
cDepartment of Pathology and Microbiology, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, Nebraska, USA 68198
Stephanie C Stotz
aResverlogix Corp., 300, 4820 Richard Road SW, Calgary, Alberta, Canada, T3E 6L1
Jan O Johansson
aResverlogix Corp., 300, 4820 Richard Road SW, Calgary, Alberta, Canada, T3E 6L1
Michael Sweeney
aResverlogix Corp., 300, 4820 Richard Road SW, Calgary, Alberta, Canada, T3E 6L1
Norman CW Wong
aResverlogix Corp., 300, 4820 Richard Road SW, Calgary, Alberta, Canada, T3E 6L1
Ewelina Kulikowski
aResverlogix Corp., 300, 4820 Richard Road SW, Calgary, Alberta, Canada, T3E 6L1
Dalia El-Gamal
bEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 NE Med Center, BCC 4.12.396, Omaha, Nebraska, USA 68198
Article usage
Posted March 11, 2021.
Bromodomain and extraterminal protein inhibitor, apabetalone (RVX-208), reduces ACE2 expression and attenuates SARS-CoV-2 infection in vitro
Dean Gilham, Audrey L Smith, Li Fu, Dalia Y Moore, Abenaya Muralidharan, St. Patrick M Reid, Stephanie C Stotz, Jan O Johansson, Michael Sweeney, Norman CW Wong, Ewelina Kulikowski, Dalia El-Gamal
bioRxiv 2021.03.10.432949; doi: https://doi.org/10.1101/2021.03.10.432949
Bromodomain and extraterminal protein inhibitor, apabetalone (RVX-208), reduces ACE2 expression and attenuates SARS-CoV-2 infection in vitro
Dean Gilham, Audrey L Smith, Li Fu, Dalia Y Moore, Abenaya Muralidharan, St. Patrick M Reid, Stephanie C Stotz, Jan O Johansson, Michael Sweeney, Norman CW Wong, Ewelina Kulikowski, Dalia El-Gamal
bioRxiv 2021.03.10.432949; doi: https://doi.org/10.1101/2021.03.10.432949
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