Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Distinct generation of subjective vividness and confidence during naturalistic memory retrieval in angular gyrus

View ORCID ProfileFuting Zou, View ORCID ProfileSze Chai Kwok
doi: https://doi.org/10.1101/2021.03.10.434526
Futing Zou
1Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics Ministry of Education, Shanghai Key Laboratory of Magnetic Resonance, Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China, 200062
5Department of Psychology, University of Oregon, Eugene, United States, 97403
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Futing Zou
Sze Chai Kwok
1Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics Ministry of Education, Shanghai Key Laboratory of Magnetic Resonance, Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China, 200062
2Division of Natural and Applied Sciences, Duke Kunshan University, Kunshan, China, 215316
3State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China, 100875
4Shanghai Changning Mental Health Center, Shanghai, China, 200335
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Sze Chai Kwok
  • For correspondence: sze-chai.kwok@st-hughs.oxon.org
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Our subjective experience of remembering guides and monitors the reconstruction of past and simulation of the future, which enables us to identify mistakes and adjust our behavior accordingly. However, it remains incompletely understood what underlies the process of subjective mnemonic experience. Here, we combined behavior, repetitive transcranial magnetic stimulation (rTMS), and functional neuroimaging to probe whether vividness and confidence are generated differently during retrieval. We found that preretrieval rTMS targeting the left angular gyrus (AnG) selectively attenuated the vividness efficiency compared to control stimulation while keeping metacognitive efficiency and objective memory accuracy unaffected. Using trial-wise data, we showed that AnG stimulation altered the mediating role of vividness in confidence in the accuracy of memory judgment. Moreover, resting-state functional connectivity of hippocampus and AnG was specifically associated with vividness efficiency, but not metacognitive efficiency across individuals. Together, these results identify the causal involvement of AnG in gauging the vividness, but not the confidence, of memory, thereby suggesting a differentiation account of conscious assessment of memory by functionally and anatomically dissociating the monitoring of vividness from confidence.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Conflict of Interest: The authors declare no competing financial interests.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted January 14, 2022.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Distinct generation of subjective vividness and confidence during naturalistic memory retrieval in angular gyrus
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Distinct generation of subjective vividness and confidence during naturalistic memory retrieval in angular gyrus
Futing Zou, Sze Chai Kwok
bioRxiv 2021.03.10.434526; doi: https://doi.org/10.1101/2021.03.10.434526
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Distinct generation of subjective vividness and confidence during naturalistic memory retrieval in angular gyrus
Futing Zou, Sze Chai Kwok
bioRxiv 2021.03.10.434526; doi: https://doi.org/10.1101/2021.03.10.434526

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4222)
  • Biochemistry (9095)
  • Bioengineering (6733)
  • Bioinformatics (23916)
  • Biophysics (12066)
  • Cancer Biology (9484)
  • Cell Biology (13720)
  • Clinical Trials (138)
  • Developmental Biology (7614)
  • Ecology (11644)
  • Epidemiology (2066)
  • Evolutionary Biology (15459)
  • Genetics (10610)
  • Genomics (14281)
  • Immunology (9447)
  • Microbiology (22749)
  • Molecular Biology (9056)
  • Neuroscience (48811)
  • Paleontology (354)
  • Pathology (1478)
  • Pharmacology and Toxicology (2558)
  • Physiology (3817)
  • Plant Biology (8299)
  • Scientific Communication and Education (1466)
  • Synthetic Biology (2285)
  • Systems Biology (6163)
  • Zoology (1295)