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Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus

Sau Yee Tsoi, Merve Öncül, Ella Svahn, Mark Robertson, Zuzanna Bogdanowicz, Christina McClure, View ORCID ProfileGülşen Sürmeli
doi: https://doi.org/10.1101/2021.03.10.434566
Sau Yee Tsoi
1University of Edinburgh, Centre for Discovery Brain Sciences, Edinburgh, UK
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Merve Öncül
1University of Edinburgh, Centre for Discovery Brain Sciences, Edinburgh, UK
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Ella Svahn
1University of Edinburgh, Centre for Discovery Brain Sciences, Edinburgh, UK
3University College London, UK
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Mark Robertson
1University of Edinburgh, Centre for Discovery Brain Sciences, Edinburgh, UK
4NHS Greater Glasgow and Clyde, UK
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Zuzanna Bogdanowicz
1University of Edinburgh, Centre for Discovery Brain Sciences, Edinburgh, UK
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Christina McClure
1University of Edinburgh, Centre for Discovery Brain Sciences, Edinburgh, UK
5Vector Core, USA
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Gülşen Sürmeli
1University of Edinburgh, Centre for Discovery Brain Sciences, Edinburgh, UK
2Simons Initiative for the Developing Brain
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  • ORCID record for Gülşen Sürmeli
  • For correspondence: gsurmeli@ed.ac.uk
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Abstract

Standard models for memory storage assume that signals reach the hippocampus from superficial layers of the entorhinal cortex (EC) and are returned to the telencephalon by projections from deep layers of the EC. Here we show that telencephalon-projecting cells in Layer 5a of the medial EC send a copy of their outputs back to the CA1 region of the hippocampus. Our results suggest that rather than serving as a relay, deep EC may coordinate hippocampal-neocortical interactions in memory consolidation.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 11, 2021.
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Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus
Sau Yee Tsoi, Merve Öncül, Ella Svahn, Mark Robertson, Zuzanna Bogdanowicz, Christina McClure, Gülşen Sürmeli
bioRxiv 2021.03.10.434566; doi: https://doi.org/10.1101/2021.03.10.434566
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Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus
Sau Yee Tsoi, Merve Öncül, Ella Svahn, Mark Robertson, Zuzanna Bogdanowicz, Christina McClure, Gülşen Sürmeli
bioRxiv 2021.03.10.434566; doi: https://doi.org/10.1101/2021.03.10.434566

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