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Human primary visual cortex shows larger population receptive fields for binocular disparity-defined stimuli

View ORCID ProfileIvan Alvarez, View ORCID ProfileSamuel A. Hurley, View ORCID ProfileAndrew J. Parker, View ORCID ProfileHolly Bridge
doi: https://doi.org/10.1101/2021.03.10.434843
Ivan Alvarez
1Oxford Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences. University of Oxford, Oxford, OX3 9DU, UK
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Samuel A. Hurley
1Oxford Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences. University of Oxford, Oxford, OX3 9DU, UK
2Departments of Neuroscience and Radiology, University of Wisconsin, Madison WI, 53705, USA
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Andrew J. Parker
3Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK
4Institut für Biologie, Otto-von-Guericke Universität, 39120 Magdeburg, Germany
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Holly Bridge
1Oxford Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences. University of Oxford, Oxford, OX3 9DU, UK
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  • For correspondence: holly.bridge@ndcn.ox.ac.uk
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1 Abstract

The visual perception of 3D depth is underpinned by the brain’s ability to combine signals from the left and right eyes to produce a neural representation of binocular disparity for perception and behavior. Electrophysiological studies of binocular disparity over the past two decades have investigated the computational role of neurons in area V1 for binocular combination, while more recent neuroimaging investigations have focused on identifying specific roles for different extrastriate visual areas in depth perception. Here we investigate the population receptive field properties of neural responses to binocular information in striate and extrastriate cortical visual areas using ultra-high field fMRI. We measured BOLD fMRI responses while participants viewed retinotopic-mapping stimuli defined by different visual properties: contrast, luminance, motion, correlated and anti-correlated stereoscopic disparity. By fitting each condition with a population receptive field model, we compared quantitatively the size of the population receptive field for disparity-specific stimulation. We found larger population receptive fields for disparity compared with contrast and luminance in area V1, the first stage of binocular combination, which likely reflects the binocular integration zone, an interpretation supported by modelling of the binocular energy model. A similar pattern was found in region LOC, where it may reflect the role of disparity as a cue for 3D shape. These findings provide insight into the binocular receptive field properties underlying processing for human stereoscopic vision.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted March 12, 2021.
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Human primary visual cortex shows larger population receptive fields for binocular disparity-defined stimuli
Ivan Alvarez, Samuel A. Hurley, Andrew J. Parker, Holly Bridge
bioRxiv 2021.03.10.434843; doi: https://doi.org/10.1101/2021.03.10.434843
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Human primary visual cortex shows larger population receptive fields for binocular disparity-defined stimuli
Ivan Alvarez, Samuel A. Hurley, Andrew J. Parker, Holly Bridge
bioRxiv 2021.03.10.434843; doi: https://doi.org/10.1101/2021.03.10.434843

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