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Oligodendrocyte Precursor Cells Sculpt the Visual System by Regulating Axonal Remodeling

Yan Xiao, Laura J Hoodless, Luigi Petrucco, View ORCID ProfileRuben Portugues, View ORCID ProfileTim Czopka
doi: https://doi.org/10.1101/2021.03.11.434829
Yan Xiao
1Institute of Neuronal Cell Biology, Technical University of Munich, Germany
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Laura J Hoodless
2Centre for Clinical Brain Sciences, University of Edinburgh, United Kingdom
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Luigi Petrucco
3Max Planck Institute of Neurobiology, Sensorimotor Control Research Group, Martinsried 82152, Germany
4Institute of Neuroscience, Technical University of Munich, Germany
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Ruben Portugues
2Centre for Clinical Brain Sciences, University of Edinburgh, United Kingdom
4Institute of Neuroscience, Technical University of Munich, Germany
5Munich Cluster for Systems Neurology (SyNergy), Germany
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  • ORCID record for Ruben Portugues
Tim Czopka
1Institute of Neuronal Cell Biology, Technical University of Munich, Germany
2Centre for Clinical Brain Sciences, University of Edinburgh, United Kingdom
5Munich Cluster for Systems Neurology (SyNergy), Germany
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  • For correspondence: Tim.Czopka@ed.ac.uk
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Abstract

Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size during formation and maturation of retinotectal connectivity, and in consequence impaired visual acuity. Therefore, OPCs fine-tune neural circuit structure and function independently of their canonical role to make myelin.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 12, 2021.
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Oligodendrocyte Precursor Cells Sculpt the Visual System by Regulating Axonal Remodeling
Yan Xiao, Laura J Hoodless, Luigi Petrucco, Ruben Portugues, Tim Czopka
bioRxiv 2021.03.11.434829; doi: https://doi.org/10.1101/2021.03.11.434829
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Oligodendrocyte Precursor Cells Sculpt the Visual System by Regulating Axonal Remodeling
Yan Xiao, Laura J Hoodless, Luigi Petrucco, Ruben Portugues, Tim Czopka
bioRxiv 2021.03.11.434829; doi: https://doi.org/10.1101/2021.03.11.434829

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