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Large-scale design and refinement of stable proteins using sequence-only models
View ORCID ProfileJedediah M. Singer, Scott Novotney, Devin Strickland, Hugh K. Haddox, Nicholas Leiby, Gabriel J. Rocklin, Cameron M. Chow, Anindya Roy, Asim K. Bera, Francis C. Motta, Longxing Cao, Eva-Maria Strauch, Tamuka M. Chidyausiku, Alex Ford, Ethan Ho, Craig O. Mackenzie, Hamed Eramian, Frank DiMaio, Gevorg Grigoryan, Matthew Vaughn, Lance J. Stewart, David Baker, Eric Klavins
doi: https://doi.org/10.1101/2021.03.12.435185
Jedediah M. Singer
1Two Six Technologies, Arlington, USA
Scott Novotney
1Two Six Technologies, Arlington, USA
Devin Strickland
2Department of Electrical and Computer Engineering, University of Washington, Seattle, USA
Hugh K. Haddox
3Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, USA
Nicholas Leiby
1Two Six Technologies, Arlington, USA
Gabriel J. Rocklin
4Department of Pharmacology and Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, USA
Cameron M. Chow
3Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, USA
Anindya Roy
3Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, USA
Asim K. Bera
3Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, USA
Francis C. Motta
5Department of Mathematical Sciences, Florida Atlantic University, Boca Raton, USA
Longxing Cao
3Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, USA
Eva-Maria Strauch
6Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, USA
Tamuka M. Chidyausiku
3Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, USA
Alex Ford
3Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, USA
Ethan Ho
7Texas Advanced Computing Center, Austin, USA
Craig O. Mackenzie
8Quantitative Biomedical Sciences Graduate Program, Dartmouth College, Hanover, USA
Hamed Eramian
9Netrias, Arlington, USA
Frank DiMaio
3Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, USA
Gevorg Grigoryan
10Departments of Computer Science and Biological Sciences, Dartmouth College, Hanover, USA
Matthew Vaughn
7Texas Advanced Computing Center, Austin, USA
Lance J. Stewart
3Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, USA
David Baker
3Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, USA
Eric Klavins
2Department of Electrical and Computer Engineering, University of Washington, Seattle, USA
Posted April 06, 2021.
Large-scale design and refinement of stable proteins using sequence-only models
Jedediah M. Singer, Scott Novotney, Devin Strickland, Hugh K. Haddox, Nicholas Leiby, Gabriel J. Rocklin, Cameron M. Chow, Anindya Roy, Asim K. Bera, Francis C. Motta, Longxing Cao, Eva-Maria Strauch, Tamuka M. Chidyausiku, Alex Ford, Ethan Ho, Craig O. Mackenzie, Hamed Eramian, Frank DiMaio, Gevorg Grigoryan, Matthew Vaughn, Lance J. Stewart, David Baker, Eric Klavins
bioRxiv 2021.03.12.435185; doi: https://doi.org/10.1101/2021.03.12.435185
Large-scale design and refinement of stable proteins using sequence-only models
Jedediah M. Singer, Scott Novotney, Devin Strickland, Hugh K. Haddox, Nicholas Leiby, Gabriel J. Rocklin, Cameron M. Chow, Anindya Roy, Asim K. Bera, Francis C. Motta, Longxing Cao, Eva-Maria Strauch, Tamuka M. Chidyausiku, Alex Ford, Ethan Ho, Craig O. Mackenzie, Hamed Eramian, Frank DiMaio, Gevorg Grigoryan, Matthew Vaughn, Lance J. Stewart, David Baker, Eric Klavins
bioRxiv 2021.03.12.435185; doi: https://doi.org/10.1101/2021.03.12.435185
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