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Recurrent structural variations of lncRNA gene CCDC26 in diffuse intrinsic pontine glioma

Lihua Zou
doi: https://doi.org/10.1101/2021.03.14.435351
Lihua Zou
Northwestern University Chicago, IL, USA
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  • For correspondence: lihuazou@gmail.com
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Abstract

We report recurrent somatic structural variations (SVs) involving long noncoding RNA (lncRNA) CCDC26 in 13% of Diffuse Intrinsic Pontine Glioma (DIPG) patients. We validate our findings using whole genome sequencing data from two independent patient cohorts. CCDC26 SVs cause increased expression of CCDC26 gene in patients. In addition, CCDC26 expression is associated with elevated expression of MYC and proliferation signature. Our findings identify CCDC26 as a novel significantly mutated gene in DIPG and highlight the importance of structural variations in pediatric brain cancer.

Competing Interest Statement

The authors have declared no competing interest.

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  • lihuazou{at}gmail.com

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted March 15, 2021.
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Recurrent structural variations of lncRNA gene CCDC26 in diffuse intrinsic pontine glioma
Lihua Zou
bioRxiv 2021.03.14.435351; doi: https://doi.org/10.1101/2021.03.14.435351
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Recurrent structural variations of lncRNA gene CCDC26 in diffuse intrinsic pontine glioma
Lihua Zou
bioRxiv 2021.03.14.435351; doi: https://doi.org/10.1101/2021.03.14.435351

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