Article Information
History
- March 16, 2021.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- Calum Gabbutt1,2,3,
- Ryan O Schenck4,5,
- Dan Weisenberger6,
- Christopher Kimberley1,
- Alison Berner1,
- Jacob Househam1,
- Eszter Lakatos1,
- Mark Robertson-Tessi4,
- Isabel Martin1,7,
- Roshani Patel1,7,
- Sue Clark7,
- Andrew Latchford7,
- Christopher Barnes2,
- Simon J Leedham5,
- Alexander RA Anderson4,*,
- Trevor A Graham1,* and
- Darryl Shibata6,*
- 1Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
- 2Department of Cell & Developmental Biology, University College London, London, WC1E 6BT, UK
- 3London Interdisciplinary Doctoral Training Programme (LIDo)
- 4Integrated Mathematical Oncology Department, Moffitt Cancer Center, Tampa, Florida 33612, USA
- 5Intestinal Stem Cell Biology Lab, Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX2 7BN
- 6University of Southern California, Keck School of Medicine, Department of Pathology, Los Angeles, CA, 90033, USA
- 7St Mark’s Hospital and Academic Institute, Harrow, London, HA1 3UJ, UK
- ↵* For correspondence: Alexander.Anderson{at}moffitt.org, t.graham{at}qmul.ac.uk and dshibata{at}usc.edu
Contributions: DS conceived the notion of oscillating molecular clocks for lineage tracing. AA, TG and DS designed the study. SL, AA, TG and DS funded and supervised the study. CG, CB and TG conceived and designed the mathematical inference framework and CG wrote the code and performed the analyses. RS, MT, AA and DS designed the blood and 2D crypt simulations and RS wrote the code and performed the analyses. DW, CK, AB and DS performed molecular assays. CG, JH, EL, RS, and DS performed bioinformatics analysis. IM, RP, SC, AL and DS provided patient materials. CG, TG and DS wrote the first draft of the manuscript and all authors approved the final version.