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Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer
View ORCID ProfileCaterina Bartolacci, View ORCID ProfileCristina Andreani, Gonçalo Vias Do Vale, View ORCID ProfileStefano Berto, Margherita Melegari, Anna C. Crouch, Dodge L. Baluya, View ORCID ProfileGeorge Kemble, Kurt Hodges, Jacqueline Starrett, Katerina Politi, Sandra L. Starnes, Daniele Lorenzini, View ORCID ProfileMaria Gabriela Raso, Luisa Solis Soto, Carmen Behrens, Humam Kadara, View ORCID ProfileBoning Gao, View ORCID ProfileDavid Gerber, Ignacio I. Wistuba, View ORCID ProfileJohn D. Minna, Jeffrey McDonald, View ORCID ProfilePier Paolo Scaglioni
doi: https://doi.org/10.1101/2021.03.18.434804
Caterina Bartolacci
1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
Cristina Andreani
1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
Gonçalo Vias Do Vale
2McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Stefano Berto
3Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Margherita Melegari
1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
Anna C. Crouch
4Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center
Dodge L. Baluya
5Tissue Imaging and Proteomics Laboratory, Washington State University, Pullman, WA 99164.
George Kemble
6Sagimet Biosciences, San Mateo, CA 94402
Kurt Hodges
7Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
Jacqueline Starrett
8Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut
Katerina Politi
8Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut
Sandra L. Starnes
9Department of Surgery, Division of Thoracic Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
Daniele Lorenzini
10Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, via Venezian 1, 20133 Milan, Italy
Maria Gabriela Raso
11Department of Translational Molecular Pathology,
Luisa Solis Soto
11Department of Translational Molecular Pathology,
Carmen Behrens
12Department of Thoracic H&N Med Oncology, The University of Texas MD Anderson Cancer Center.
Humam Kadara
11Department of Translational Molecular Pathology,
Boning Gao
13Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
David Gerber
13Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Ignacio I. Wistuba
11Department of Translational Molecular Pathology,
John D. Minna
13Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Jeffrey McDonald
2McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Pier Paolo Scaglioni
1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
Article usage
Posted March 19, 2021.
Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer
Caterina Bartolacci, Cristina Andreani, Gonçalo Vias Do Vale, Stefano Berto, Margherita Melegari, Anna C. Crouch, Dodge L. Baluya, George Kemble, Kurt Hodges, Jacqueline Starrett, Katerina Politi, Sandra L. Starnes, Daniele Lorenzini, Maria Gabriela Raso, Luisa Solis Soto, Carmen Behrens, Humam Kadara, Boning Gao, David Gerber, Ignacio I. Wistuba, John D. Minna, Jeffrey McDonald, Pier Paolo Scaglioni
bioRxiv 2021.03.18.434804; doi: https://doi.org/10.1101/2021.03.18.434804
Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer
Caterina Bartolacci, Cristina Andreani, Gonçalo Vias Do Vale, Stefano Berto, Margherita Melegari, Anna C. Crouch, Dodge L. Baluya, George Kemble, Kurt Hodges, Jacqueline Starrett, Katerina Politi, Sandra L. Starnes, Daniele Lorenzini, Maria Gabriela Raso, Luisa Solis Soto, Carmen Behrens, Humam Kadara, Boning Gao, David Gerber, Ignacio I. Wistuba, John D. Minna, Jeffrey McDonald, Pier Paolo Scaglioni
bioRxiv 2021.03.18.434804; doi: https://doi.org/10.1101/2021.03.18.434804
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