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The Dual-Antigen Ad5 COVID-19 Vaccine Delivered as an Intranasal Plus Subcutaneous Prime Elicits Th1 Dominant T-Cell and Humoral Responses in CD-1 Mice
Adrian Rice, Mohit Verma, Annie Shin, Lise Zakin, Peter Sieling, Shiho Tanaka, Joseph Balint, Kyle Dinkins, Helty Adisetiyo, Brett Morimoto, Wendy Higashide, Justin Taft, View ORCID ProfileRosheel Patel, Sofija Buta, Marta Martin-Fernandez, Dusan Bogunovic, Patricia Spilman, Elizabeth Gabitzsch, Jeffrey T. Safrit, Shahrooz Rabizadeh, Kayvan Niazi, View ORCID ProfilePatrick Soon-Shiong
doi: https://doi.org/10.1101/2021.03.22.436476
Adrian Rice
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Mohit Verma
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Annie Shin
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Lise Zakin
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Peter Sieling
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Shiho Tanaka
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Joseph Balint
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Kyle Dinkins
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Helty Adisetiyo
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Brett Morimoto
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Wendy Higashide
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Justin Taft
2Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
3Department of Pediatrics, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
Rosheel Patel
2Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
3Department of Pediatrics, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
Sofija Buta
2Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
3Department of Pediatrics, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
4Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
Marta Martin-Fernandez
2Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
3Department of Pediatrics, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
4Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
5Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
6Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
Dusan Bogunovic
2Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
3Department of Pediatrics, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
4Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
5Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
6Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1 Gustave Lane, Levy Place, New York, NY 10029-5674, USA
Patricia Spilman
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Elizabeth Gabitzsch
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Jeffrey T. Safrit
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Shahrooz Rabizadeh
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Kayvan Niazi
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Patrick Soon-Shiong
1ImmunityBio, Inc., 9920 Jefferson Blvd, Culver City, CA 90232, USA
Article usage
Posted March 26, 2021.
The Dual-Antigen Ad5 COVID-19 Vaccine Delivered as an Intranasal Plus Subcutaneous Prime Elicits Th1 Dominant T-Cell and Humoral Responses in CD-1 Mice
Adrian Rice, Mohit Verma, Annie Shin, Lise Zakin, Peter Sieling, Shiho Tanaka, Joseph Balint, Kyle Dinkins, Helty Adisetiyo, Brett Morimoto, Wendy Higashide, Justin Taft, Rosheel Patel, Sofija Buta, Marta Martin-Fernandez, Dusan Bogunovic, Patricia Spilman, Elizabeth Gabitzsch, Jeffrey T. Safrit, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong
bioRxiv 2021.03.22.436476; doi: https://doi.org/10.1101/2021.03.22.436476
The Dual-Antigen Ad5 COVID-19 Vaccine Delivered as an Intranasal Plus Subcutaneous Prime Elicits Th1 Dominant T-Cell and Humoral Responses in CD-1 Mice
Adrian Rice, Mohit Verma, Annie Shin, Lise Zakin, Peter Sieling, Shiho Tanaka, Joseph Balint, Kyle Dinkins, Helty Adisetiyo, Brett Morimoto, Wendy Higashide, Justin Taft, Rosheel Patel, Sofija Buta, Marta Martin-Fernandez, Dusan Bogunovic, Patricia Spilman, Elizabeth Gabitzsch, Jeffrey T. Safrit, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong
bioRxiv 2021.03.22.436476; doi: https://doi.org/10.1101/2021.03.22.436476
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