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DNA replication during acute MEK inhibition drives acquisition of resistance through amplification of the BRAF oncogene

View ORCID ProfilePrasanna Channathodiyil, View ORCID ProfileAnne Segonds-Pichon, Paul D. Smith, View ORCID ProfileSimon J. Cook, View ORCID ProfileJonathan Houseley
doi: https://doi.org/10.1101/2021.03.23.436572
Prasanna Channathodiyil
1Epigenetics Programme, Babraham Institute, Cambridge, UK
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Anne Segonds-Pichon
3Babraham Bioinformatics, Babraham Institute, Cambridge, UK
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Paul D. Smith
4Oncology R&D, AstraZeneca CRUK Cambridge Institute, Cambridge, UK
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Simon J. Cook
5Signalling programme, Babraham Institute, Cambridge, UK
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Jonathan Houseley
1Epigenetics Programme, Babraham Institute, Cambridge, UK
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  • For correspondence: jon.houseley@babraham.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2021.03.23.436572
History 
  • March 23, 2021.

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  • You are currently viewing Version 1 of this article (March 23, 2021 - 16:36).
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Prasanna Channathodiyil1,
  2. Anne Segonds-Pichon3,
  3. Paul D. Smith4,
  4. Simon J. Cook5 and
  5. Jonathan Houseley1,*
  1. 1Epigenetics Programme, Babraham Institute, Cambridge, UK
  2. 3Babraham Bioinformatics, Babraham Institute, Cambridge, UK
  3. 4Oncology R&D, AstraZeneca CRUK Cambridge Institute, Cambridge, UK
  4. 5Signalling programme, Babraham Institute, Cambridge, UK
  1. ↵*Corresponding author: jon.houseley{at}babraham.ac.uk
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Posted March 23, 2021.
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DNA replication during acute MEK inhibition drives acquisition of resistance through amplification of the BRAF oncogene
Prasanna Channathodiyil, Anne Segonds-Pichon, Paul D. Smith, Simon J. Cook, Jonathan Houseley
bioRxiv 2021.03.23.436572; doi: https://doi.org/10.1101/2021.03.23.436572
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DNA replication during acute MEK inhibition drives acquisition of resistance through amplification of the BRAF oncogene
Prasanna Channathodiyil, Anne Segonds-Pichon, Paul D. Smith, Simon J. Cook, Jonathan Houseley
bioRxiv 2021.03.23.436572; doi: https://doi.org/10.1101/2021.03.23.436572

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