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Degradable endovascular neural interface for minimally invasive neural recording and stimulation

Adele Fanelli, Laura Ferlauto, Elodie Geneviève Zollinger, Olivier Brina, Philippe Reymond, Paolo Machi, Diego Ghezzi
doi: https://doi.org/10.1101/2021.03.24.436737
Adele Fanelli
1Medtronic Chair in Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École polytechnique fédérale de Lausanne, Chemin des Mines 9, 1202 Geneva, Switzerland
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Laura Ferlauto
1Medtronic Chair in Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École polytechnique fédérale de Lausanne, Chemin des Mines 9, 1202 Geneva, Switzerland
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Elodie Geneviève Zollinger
1Medtronic Chair in Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École polytechnique fédérale de Lausanne, Chemin des Mines 9, 1202 Geneva, Switzerland
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Olivier Brina
2Division of of Neuroradiology, Geneva University Hospital, Geneva, Switzerland
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Philippe Reymond
2Division of of Neuroradiology, Geneva University Hospital, Geneva, Switzerland
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Paolo Machi
2Division of of Neuroradiology, Geneva University Hospital, Geneva, Switzerland
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Diego Ghezzi
1Medtronic Chair in Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École polytechnique fédérale de Lausanne, Chemin des Mines 9, 1202 Geneva, Switzerland
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  • For correspondence: diego.ghezzi@epfl.ch
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Abstract

Neural recording and stimulation have been widely used to mitigate traumatic injuries, neurodegenerative diseases or mental disorders. Most neural interfaces commonly require invasive surgery, potentially entailing both transient and permanent complications. A promising strategy designed to overcome these risks involves exploiting the cerebrovascular system as an access route to the neural tissue. Here we present a novel endovascular neural interface for neural recording and stimulation, fully polymeric and degradable. This concept might allow for better integration of the device in the body, reduced inflammatory reaction, the possibility of replacing the implant after degradation, and avoiding removal surgeries. The vasculature’s strategic distribution and the use of soft polymers for the device’s fabrication will permit targeting both the brain vasculature and the peripheral system. Therefore, this novel endovascular neural interface will broaden the range of applications from neurological diseases and mental disorders to bioelectronics medicine.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵* E-mail: diego.ghezzi{at}epfl.ch

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted March 25, 2021.
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Degradable endovascular neural interface for minimally invasive neural recording and stimulation
Adele Fanelli, Laura Ferlauto, Elodie Geneviève Zollinger, Olivier Brina, Philippe Reymond, Paolo Machi, Diego Ghezzi
bioRxiv 2021.03.24.436737; doi: https://doi.org/10.1101/2021.03.24.436737
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Degradable endovascular neural interface for minimally invasive neural recording and stimulation
Adele Fanelli, Laura Ferlauto, Elodie Geneviève Zollinger, Olivier Brina, Philippe Reymond, Paolo Machi, Diego Ghezzi
bioRxiv 2021.03.24.436737; doi: https://doi.org/10.1101/2021.03.24.436737

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