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2,3,7,8-Tetrachlorodibenzo-p-dioxin elicited decreases in cobalamin inhibits methylmalonyl-CoA mutase activity redirecting propionyl-CoA metabolism to the β–oxidation-like pathway resulting in hepatic accumulation of the toxic intermediate acrylyl-CoA
Karina Orlowska, Russ R. Fling, Rance Nault, Tim Zacharewski
doi: https://doi.org/10.1101/2021.03.24.436837
Karina Orlowska
1Biochemistry & Molecular Biology,
2Institute for Integrative Toxicology
Russ R. Fling
2Institute for Integrative Toxicology
3Microbiology & Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA
Rance Nault
1Biochemistry & Molecular Biology,
2Institute for Integrative Toxicology
Tim Zacharewski
1Biochemistry & Molecular Biology,
2Institute for Integrative Toxicology
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Posted March 25, 2021.
2,3,7,8-Tetrachlorodibenzo-p-dioxin elicited decreases in cobalamin inhibits methylmalonyl-CoA mutase activity redirecting propionyl-CoA metabolism to the β–oxidation-like pathway resulting in hepatic accumulation of the toxic intermediate acrylyl-CoA
Karina Orlowska, Russ R. Fling, Rance Nault, Tim Zacharewski
bioRxiv 2021.03.24.436837; doi: https://doi.org/10.1101/2021.03.24.436837
2,3,7,8-Tetrachlorodibenzo-p-dioxin elicited decreases in cobalamin inhibits methylmalonyl-CoA mutase activity redirecting propionyl-CoA metabolism to the β–oxidation-like pathway resulting in hepatic accumulation of the toxic intermediate acrylyl-CoA
Karina Orlowska, Russ R. Fling, Rance Nault, Tim Zacharewski
bioRxiv 2021.03.24.436837; doi: https://doi.org/10.1101/2021.03.24.436837
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