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Role of protein degradation in growth laws

View ORCID ProfileLudovico Calabrese, View ORCID ProfileJacopo Grilli, View ORCID ProfileMatteo Osella, Christopher P Kempes, View ORCID ProfileMarco Cosentino Lagomarsino, View ORCID ProfileLuca Ciandrini
doi: https://doi.org/10.1101/2021.03.25.436692
Ludovico Calabrese
1IFOM Foundation, FIRC Institute for Molecular Oncology, via Adamello 16, Milan, Italy
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  • For correspondence: ludovico.calabrese@ifom.eu marco.cosentino-lagomarsino@ifom.eu luca.ciandrini@umontpellier.fr
Jacopo Grilli
2The Abdus Salam International Centre for Theoretical Physics (ICTP), Str. Costiera 11, 34151 Trieste, Italy
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Matteo Osella
3Physics Department, University of Turin and INFN, via P. Giuria 1, 10125 Turin, Italy
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Christopher P Kempes
4The Santa Fe Institute, Santa Fe, NM, United States
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Marco Cosentino Lagomarsino
1IFOM Foundation, FIRC Institute for Molecular Oncology, via Adamello 16, Milan, Italy
5Dipartimento di Fisica, Università degli Studi di Milano, via Celoria 16, Milan, Italy
6INFN sezione di Milano, via Celoria 16, Milan, Italy
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  • For correspondence: ludovico.calabrese@ifom.eu marco.cosentino-lagomarsino@ifom.eu luca.ciandrini@umontpellier.fr
Luca Ciandrini
7Centre de Biologie Structurale (CBS), CNRS, INSERM, Univ Montpellier, Montpellier 34090, France
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  • For correspondence: ludovico.calabrese@ifom.eu marco.cosentino-lagomarsino@ifom.eu luca.ciandrini@umontpellier.fr
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Abstract

Growing cells adopt common basic strategies to achieve optimal resource allocation under limited resource availability. Our current understanding of such “growth laws” neglects degradation, assuming that it occurs slowly compared to the cell cycle duration. Here we argue that this assumption cannot hold at slow growth, leading to strong qualitative consequences. We propose a simple framework showing that at slow growth protein degradation is balanced by a fraction of “maintenance” ribosomes. Through a detailed analysis of compiled data, we show how this model is predictive with E. coli data and agrees with S. cerevisiae measurements. Intriguingly, model and data show an increased protein degradation at slow growth, which we interpret as a consequence of active waste management and/or recycling. Our results highlight protein turnover as an underrated factor for our understanding of growth laws across kingdoms.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • http://dx.doi.org/10.17632/85pxpdsx38.1

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 26, 2021.
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Role of protein degradation in growth laws
Ludovico Calabrese, Jacopo Grilli, Matteo Osella, Christopher P Kempes, Marco Cosentino Lagomarsino, Luca Ciandrini
bioRxiv 2021.03.25.436692; doi: https://doi.org/10.1101/2021.03.25.436692
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Role of protein degradation in growth laws
Ludovico Calabrese, Jacopo Grilli, Matteo Osella, Christopher P Kempes, Marco Cosentino Lagomarsino, Luca Ciandrini
bioRxiv 2021.03.25.436692; doi: https://doi.org/10.1101/2021.03.25.436692

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