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INPP4B promotes leukemia by restricting leukemic stem cell differentiation through regulation of lysosomal functions
John F. Woolley, Keyue Chen, Gizem E. Genc, Daniel K.C. Lee, Irakli Dzneladze, Ruijuan He, Martino M. Gabra, Golam T. Saffi, Meong Hi Son, Erwin M. Schoof, Stephanie Z. Xie, Max Kotlyar, Ayesha Rashid, Jean Vacher, Igor Jurisica, John E. Dick, Roberto J. Botelho, Mark D. Minden, Leonardo Salmena
doi: https://doi.org/10.1101/2021.03.25.437029
John F. Woolley
1Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
2Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada
Keyue Chen
1Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Gizem E. Genc
3Department of Chemistry and Biology, Ryerson University, Toronto, Ontario M5B 2K3, Canada
Daniel K.C. Lee
1Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Irakli Dzneladze
2Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada
Ruijuan He
2Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada
Martino M. Gabra
1Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Golam T. Saffi
1Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Meong Hi Son
1Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
2Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada
Erwin M. Schoof
2Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada
Stephanie Z. Xie
2Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada
Max Kotlyar
5Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, University Health Network; Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network, Toronto, Ontario M5T 0S8, Canada
Ayesha Rashid
2Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada
Jean Vacher
4Institut de Recherches Cliniques de Montréal (IRCM), Département de Médecine, Université de Montréal, Montréal, Québec H2W 1R7, Canada
Igor Jurisica
5Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, University Health Network; Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network, Toronto, Ontario M5T 0S8, Canada
6Department of Computer Science, University of Toronto, Toronto, Ontario M5T 3A1, Canada
7Departments of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada
8Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia
John E. Dick
2Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada
9Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
10Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada
Roberto J. Botelho
3Department of Chemistry and Biology, Ryerson University, Toronto, Ontario M5B 2K3, Canada
Mark D. Minden
2Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada
7Departments of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada
Leonardo Salmena
1Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
2Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada
Article usage
Posted March 25, 2021.
INPP4B promotes leukemia by restricting leukemic stem cell differentiation through regulation of lysosomal functions
John F. Woolley, Keyue Chen, Gizem E. Genc, Daniel K.C. Lee, Irakli Dzneladze, Ruijuan He, Martino M. Gabra, Golam T. Saffi, Meong Hi Son, Erwin M. Schoof, Stephanie Z. Xie, Max Kotlyar, Ayesha Rashid, Jean Vacher, Igor Jurisica, John E. Dick, Roberto J. Botelho, Mark D. Minden, Leonardo Salmena
bioRxiv 2021.03.25.437029; doi: https://doi.org/10.1101/2021.03.25.437029
INPP4B promotes leukemia by restricting leukemic stem cell differentiation through regulation of lysosomal functions
John F. Woolley, Keyue Chen, Gizem E. Genc, Daniel K.C. Lee, Irakli Dzneladze, Ruijuan He, Martino M. Gabra, Golam T. Saffi, Meong Hi Son, Erwin M. Schoof, Stephanie Z. Xie, Max Kotlyar, Ayesha Rashid, Jean Vacher, Igor Jurisica, John E. Dick, Roberto J. Botelho, Mark D. Minden, Leonardo Salmena
bioRxiv 2021.03.25.437029; doi: https://doi.org/10.1101/2021.03.25.437029
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