P2X2 receptor subunit interfaces are missense variant hotspots where mutations tend to increase apparent ATP affinity

Federica Gasparri; Debayan Sarkar; Sarune Bielickaite; Mette Homann Poulsen; Alexander Sebastian Hauser; Stephan Alexander Pless

doi:10.1101/2021.03.26.436616

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P2X2 receptor subunit interfaces are missense variant hotspots where mutations tend to increase apparent ATP affinity

View ORCID ProfileFederica Gasparri, View ORCID ProfileDebayan Sarkar, Sarune Bielickaite, View ORCID ProfileMette Homann Poulsen, View ORCID ProfileAlexander Sebastian Hauser, View ORCID ProfileStephan Alexander Pless

doi: https://doi.org/10.1101/2021.03.26.436616

Federica Gasparri

Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark

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ORCID record for Federica Gasparri

Debayan Sarkar

Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark

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Sarune Bielickaite

Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark

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Mette Homann Poulsen

Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark

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Alexander Sebastian Hauser

Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark

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For correspondence: stephan.pless@sund.ku.dk alexander.hauser@sund.ku.dk

Stephan Alexander Pless

Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark

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For correspondence: stephan.pless@sund.ku.dk alexander.hauser@sund.ku.dk

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Posted January 17, 2022.

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P2X2 receptor subunit interfaces are missense variant hotspots where mutations tend to increase apparent ATP affinity

Federica Gasparri, Debayan Sarkar, Sarune Bielickaite, Mette Homann Poulsen, Alexander Sebastian Hauser, Stephan Alexander Pless

bioRxiv 2021.03.26.436616; doi: https://doi.org/10.1101/2021.03.26.436616

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P2X2 receptor subunit interfaces are missense variant hotspots where mutations tend to increase apparent ATP affinity

Federica Gasparri, Debayan Sarkar, Sarune Bielickaite, Mette Homann Poulsen, Alexander Sebastian Hauser, Stephan Alexander Pless

bioRxiv 2021.03.26.436616; doi: https://doi.org/10.1101/2021.03.26.436616

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