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Kenyan Traditional Medicine: Exploring Old Solutions to the Modern Antibacterial Crises Through Natural Products Chemistry

Fidensio K. Ndegwa, Chaitanya Kondam, Debarati Ghose, Taiwo E. Esan, Zohra Sattar Waxali, Margaret E. Miller, Rangaswamy Meganathan, Nicholas K. Gikonyo, Paul K. Mbugua, Paul O. Okemo, View ORCID ProfileTimothy J. Hagen
doi: https://doi.org/10.1101/2021.03.26.436821
Fidensio K. Ndegwa
aDepartment of Pharmacognosy, Pharmaceutical Chemistry and Pharmaceutical & Industrial Pharmacy, Kenyatta University, Nairobi, Kenya.
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Chaitanya Kondam
bDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL, USA.
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Debarati Ghose
cDepartment of Biological Sciences, Northern Illinois University, DeKalb, IL, USA.
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Taiwo E. Esan
bDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL, USA.
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Zohra Sattar Waxali
bDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL, USA.
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Margaret E. Miller
bDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL, USA.
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Rangaswamy Meganathan
cDepartment of Biological Sciences, Northern Illinois University, DeKalb, IL, USA.
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Nicholas K. Gikonyo
aDepartment of Pharmacognosy, Pharmaceutical Chemistry and Pharmaceutical & Industrial Pharmacy, Kenyatta University, Nairobi, Kenya.
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Paul K. Mbugua
dDepartment of Plant sciences, Kenyatta University, Nairobi, Kenya.
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Paul O. Okemo
eDepartment of Microbiology, Kenyatta University, Nairobi, Kenya.
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Timothy J. Hagen
bDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL, USA.
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  • ORCID record for Timothy J. Hagen
  • For correspondence: thagen@niu.edu
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Abstract

Infectious diseases are a major cause of morbidity and mortality around the world, accounting for approximately 50% of all deaths in tropical countries. Despite remarkable progress in the field of microbiology, inability to control or mitigate, epidemics caused by drug-resistant microorganisms pose a serious health hazard to the global population. New therapeutic strategies must be developed as a global initiative for the prevention and control of infectious diseases. This study focuses on Kenyan medicinal plants and their activity against bacteria. Plant extracts obtained from seven Kenyan plants used in traditional medicine, were screened for their antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, and Mycobacterium smegmatis. Extracts from all these plants showed antibacterial activity against at least one of the tested organisms at a concentration of 2 mg/mL. Chemical screening showed the presence of different classes of phytochemicals such as alkaloids, terpenes, tannins, in some active extracts.

Competing Interest Statement

The authors have declared no competing interest.

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Posted March 28, 2021.
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Kenyan Traditional Medicine: Exploring Old Solutions to the Modern Antibacterial Crises Through Natural Products Chemistry
Fidensio K. Ndegwa, Chaitanya Kondam, Debarati Ghose, Taiwo E. Esan, Zohra Sattar Waxali, Margaret E. Miller, Rangaswamy Meganathan, Nicholas K. Gikonyo, Paul K. Mbugua, Paul O. Okemo, Timothy J. Hagen
bioRxiv 2021.03.26.436821; doi: https://doi.org/10.1101/2021.03.26.436821
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Kenyan Traditional Medicine: Exploring Old Solutions to the Modern Antibacterial Crises Through Natural Products Chemistry
Fidensio K. Ndegwa, Chaitanya Kondam, Debarati Ghose, Taiwo E. Esan, Zohra Sattar Waxali, Margaret E. Miller, Rangaswamy Meganathan, Nicholas K. Gikonyo, Paul K. Mbugua, Paul O. Okemo, Timothy J. Hagen
bioRxiv 2021.03.26.436821; doi: https://doi.org/10.1101/2021.03.26.436821

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