Aberrant glycosylation of anti-SARS-CoV-2 IgG is a pro-thrombotic stimulus for platelets

Alexander P Bye; Willianne Hoepel; Joanne L Mitchell; Sophie Jégouic; Silvia Loureiro; Tanya Sage; Steven de Taeye; Marit van Gils; Neline Kriek; Nichola Cooper; Ian Jones; Jeroen den Dunnen; Jonathan M Gibbins

doi:10.1101/2021.03.26.437014

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Aberrant glycosylation of anti-SARS-CoV-2 IgG is a pro-thrombotic stimulus for platelets

Alexander P Bye, Willianne Hoepel, Joanne L Mitchell, Sophie Jégouic, Silvia Loureiro, Tanya Sage, Steven de Taeye, View ORCID ProfileMarit van Gils, Neline Kriek, Nichola Cooper, Ian Jones, Jeroen den Dunnen, Jonathan M Gibbins

doi: https://doi.org/10.1101/2021.03.26.437014

Alexander P Bye

1Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, United Kingdom

2School of Biological Sciences, University of Reading, UK

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Willianne Hoepel

3Department of Rheumatology and Clinical Immunology, Amsterdam UMC, Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands

4Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Joanne L Mitchell

1Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, United Kingdom

5Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham

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Sophie Jégouic

2School of Biological Sciences, University of Reading, UK

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Silvia Loureiro

2School of Biological Sciences, University of Reading, UK

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Tanya Sage

1Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, United Kingdom

2School of Biological Sciences, University of Reading, UK

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Steven de Taeye

6Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands

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Marit van Gils

6Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands

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ORCID record for Marit van Gils

Neline Kriek

1Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, United Kingdom

2School of Biological Sciences, University of Reading, UK

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Nichola Cooper

7Hammersmith Hospital, Imperial College London, London, UK

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Ian Jones

2School of Biological Sciences, University of Reading, UK

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Jeroen den Dunnen

3Department of Rheumatology and Clinical Immunology, Amsterdam UMC, Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands

4Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Jonathan M Gibbins

1Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, United Kingdom

2School of Biological Sciences, University of Reading, UK

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For correspondence: j.m.gibbins@reading.ac.uk

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Posted March 26, 2021.

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Aberrant glycosylation of anti-SARS-CoV-2 IgG is a pro-thrombotic stimulus for platelets

Alexander P Bye, Willianne Hoepel, Joanne L Mitchell, Sophie Jégouic, Silvia Loureiro, Tanya Sage, Steven de Taeye, Marit van Gils, Neline Kriek, Nichola Cooper, Ian Jones, Jeroen den Dunnen, Jonathan M Gibbins

bioRxiv 2021.03.26.437014; doi: https://doi.org/10.1101/2021.03.26.437014

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