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Systematic Profiling of Temperature- and Retinal-Sensitive Rhodopsin Variants by Deep Mutational Scanning

Andrew G. McKee, Charles P. Kuntz, Joseph T. Ortega, Hope Woods, Francis J. Roushar, View ORCID ProfileJens Meiler, Beata Jastrzebska, View ORCID ProfileJonathan P. Schlebach
doi: https://doi.org/10.1101/2021.03.26.437229
Andrew G. McKee
1Department of Chemistry, Indiana University, Bloomington, Indiana, USA
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Charles P. Kuntz
1Department of Chemistry, Indiana University, Bloomington, Indiana, USA
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Joseph T. Ortega
2Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA
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Hope Woods
3Department of Chemistry, Vanderbilt University, Nashville, TN, USA
4Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, USA
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Francis J. Roushar
1Department of Chemistry, Indiana University, Bloomington, Indiana, USA
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Jens Meiler
3Department of Chemistry, Vanderbilt University, Nashville, TN, USA
5Institute for Drug Development, Leipzig University, Leipzig, SAC, Germany
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  • ORCID record for Jens Meiler
Beata Jastrzebska
2Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA
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Jonathan P. Schlebach
1Department of Chemistry, Indiana University, Bloomington, Indiana, USA
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  • ORCID record for Jonathan P. Schlebach
  • For correspondence: jschleba@indiana.edu
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Article Information

doi 
https://doi.org/10.1101/2021.03.26.437229
History 
  • March 26, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Andrew G. McKee1,†,
  2. Charles P. Kuntz1,†,
  3. Joseph T. Ortega2,
  4. Hope Woods3,4,
  5. Francis J. Roushar1,
  6. Jens Meiler3,5,
  7. Beata Jastrzebska2 and
  8. Jonathan P. Schlebach1,*
  1. 1Department of Chemistry, Indiana University, Bloomington, Indiana, USA
  2. 2Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA
  3. 3Department of Chemistry, Vanderbilt University, Nashville, TN, USA
  4. 4Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, USA
  5. 5Institute for Drug Development, Leipzig University, Leipzig, SAC, Germany
  1. ↵*Corresponding author E-mail address: jschleba{at}indiana.edu
  1. ↵† Authors contributed equally

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Posted March 26, 2021.
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Systematic Profiling of Temperature- and Retinal-Sensitive Rhodopsin Variants by Deep Mutational Scanning
Andrew G. McKee, Charles P. Kuntz, Joseph T. Ortega, Hope Woods, Francis J. Roushar, Jens Meiler, Beata Jastrzebska, Jonathan P. Schlebach
bioRxiv 2021.03.26.437229; doi: https://doi.org/10.1101/2021.03.26.437229
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Systematic Profiling of Temperature- and Retinal-Sensitive Rhodopsin Variants by Deep Mutational Scanning
Andrew G. McKee, Charles P. Kuntz, Joseph T. Ortega, Hope Woods, Francis J. Roushar, Jens Meiler, Beata Jastrzebska, Jonathan P. Schlebach
bioRxiv 2021.03.26.437229; doi: https://doi.org/10.1101/2021.03.26.437229

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