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A lipid nanoparticle RBD-hFc mRNA vaccine protects hACE2 transgenic mice against lethal SARS-CoV-2 infection
Uri Elia, Shahar Rotem, Erez Bar-Haim, Srinivas Ramishetti, Gonna Somu Naidu, David Gur, Moshe Aftalion, Ma’ayan Israeli, Adi Bercovich-Kinori, Ron Alcalay, Efi Makdasi, Theodor Chitlaru, Ronit Rosenfeld, Tomer Israely, Sharon Melamed, Inbal Abutbul Ionita, Dganit Danino, Dan Peer, Ofer Cohen
doi: https://doi.org/10.1101/2021.03.29.436639
Uri Elia
1Laboratory of Precision NanoMedicine, Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
2Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 69978, Israel
3Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
4Cancer Biology Research Center, Tel Aviv University, Tel Aviv, 69978 Israel
5Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100 Israel
Shahar Rotem
5Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100 Israel
Erez Bar-Haim
5Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100 Israel
Srinivas Ramishetti
1Laboratory of Precision NanoMedicine, Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
2Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 69978, Israel
3Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
4Cancer Biology Research Center, Tel Aviv University, Tel Aviv, 69978 Israel
Gonna Somu Naidu
1Laboratory of Precision NanoMedicine, Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
2Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 69978, Israel
3Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
4Cancer Biology Research Center, Tel Aviv University, Tel Aviv, 69978 Israel
David Gur
5Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100 Israel
Moshe Aftalion
5Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100 Israel
Ma’ayan Israeli
5Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100 Israel
Adi Bercovich-Kinori
5Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100 Israel
Ron Alcalay
5Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100 Israel
Efi Makdasi
6Department of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona 76100 Israel
Theodor Chitlaru
5Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100 Israel
Ronit Rosenfeld
5Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100 Israel
Tomer Israely
6Department of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona 76100 Israel
Sharon Melamed
6Department of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona 76100 Israel
Inbal Abutbul Ionita
7CryoEM Laboratory of Soft Matter, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel
Dganit Danino
7CryoEM Laboratory of Soft Matter, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel
Dan Peer
1Laboratory of Precision NanoMedicine, Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
2Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 69978, Israel
3Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
4Cancer Biology Research Center, Tel Aviv University, Tel Aviv, 69978 Israel
Ofer Cohen
5Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100 Israel
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Posted March 29, 2021.
A lipid nanoparticle RBD-hFc mRNA vaccine protects hACE2 transgenic mice against lethal SARS-CoV-2 infection
Uri Elia, Shahar Rotem, Erez Bar-Haim, Srinivas Ramishetti, Gonna Somu Naidu, David Gur, Moshe Aftalion, Ma’ayan Israeli, Adi Bercovich-Kinori, Ron Alcalay, Efi Makdasi, Theodor Chitlaru, Ronit Rosenfeld, Tomer Israely, Sharon Melamed, Inbal Abutbul Ionita, Dganit Danino, Dan Peer, Ofer Cohen
bioRxiv 2021.03.29.436639; doi: https://doi.org/10.1101/2021.03.29.436639
A lipid nanoparticle RBD-hFc mRNA vaccine protects hACE2 transgenic mice against lethal SARS-CoV-2 infection
Uri Elia, Shahar Rotem, Erez Bar-Haim, Srinivas Ramishetti, Gonna Somu Naidu, David Gur, Moshe Aftalion, Ma’ayan Israeli, Adi Bercovich-Kinori, Ron Alcalay, Efi Makdasi, Theodor Chitlaru, Ronit Rosenfeld, Tomer Israely, Sharon Melamed, Inbal Abutbul Ionita, Dganit Danino, Dan Peer, Ofer Cohen
bioRxiv 2021.03.29.436639; doi: https://doi.org/10.1101/2021.03.29.436639
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