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Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry
View ORCID ProfileEdward R. Kastenhuber, Javier A. Jaimes, Jared L. Johnson, Marisa Mercadante, Frauke Muecksch, Yiska Weisblum, Yaron Bram, Robert E. Schwartz, Gary R. Whittaker, Lewis C. Cantley
doi: https://doi.org/10.1101/2021.03.31.437960
Edward R. Kastenhuber
1Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York, NY, USA
Javier A. Jaimes
2Department of Microbiology and Immunology, Cornell University, Ithaca, New York, USA
Jared L. Johnson
1Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York, NY, USA
Marisa Mercadante
1Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York, NY, USA
Frauke Muecksch
3Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA
Yiska Weisblum
3Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA
Yaron Bram
4Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA
Robert E. Schwartz
4Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA
5Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA
Gary R. Whittaker
2Department of Microbiology and Immunology, Cornell University, Ithaca, New York, USA
Lewis C. Cantley
1Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York, NY, USA
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Posted July 30, 2021.
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry
Edward R. Kastenhuber, Javier A. Jaimes, Jared L. Johnson, Marisa Mercadante, Frauke Muecksch, Yiska Weisblum, Yaron Bram, Robert E. Schwartz, Gary R. Whittaker, Lewis C. Cantley
bioRxiv 2021.03.31.437960; doi: https://doi.org/10.1101/2021.03.31.437960
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry
Edward R. Kastenhuber, Javier A. Jaimes, Jared L. Johnson, Marisa Mercadante, Frauke Muecksch, Yiska Weisblum, Yaron Bram, Robert E. Schwartz, Gary R. Whittaker, Lewis C. Cantley
bioRxiv 2021.03.31.437960; doi: https://doi.org/10.1101/2021.03.31.437960
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