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Regimes and mechanisms of transient amplification in abstract and biological networks

Georgia Christodoulou, View ORCID ProfileTim P. Vogels, View ORCID ProfileEverton J. Agnes
doi: https://doi.org/10.1101/2021.04.01.437964
Georgia Christodoulou
1Centre for Neural Circuits and Behaviour, University of Oxford, OX1 3SR Oxford, United Kingdom
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  • For correspondence: georgia.christodoul@gmail.com everton.agnes@gmail.com
Tim P. Vogels
1Centre for Neural Circuits and Behaviour, University of Oxford, OX1 3SR Oxford, United Kingdom
2Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria
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Everton J. Agnes
1Centre for Neural Circuits and Behaviour, University of Oxford, OX1 3SR Oxford, United Kingdom
3Biozentrum, University of Basel, 4056 Basel, Switzerland
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  • For correspondence: georgia.christodoul@gmail.com everton.agnes@gmail.com
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Abstract

We use upper triangular matrices as abstract representations of neuronal networks and directly manipulate their eigenspectra and non-normality to explore different regimes of transient amplification. Counter–intuitively, manipulating the imaginary distribution can lead to highly amplifying regimes. This is noteworthy, because biological networks are constrained by Dale’s law and the non-existence of neuronal self-loops, limiting the range of manipulations in the real dimension. Within these constraints we can further manipulate transient amplification by controlling global inhibition.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted April 05, 2021.
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Regimes and mechanisms of transient amplification in abstract and biological networks
Georgia Christodoulou, Tim P. Vogels, Everton J. Agnes
bioRxiv 2021.04.01.437964; doi: https://doi.org/10.1101/2021.04.01.437964
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Regimes and mechanisms of transient amplification in abstract and biological networks
Georgia Christodoulou, Tim P. Vogels, Everton J. Agnes
bioRxiv 2021.04.01.437964; doi: https://doi.org/10.1101/2021.04.01.437964

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