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Acylation of the incretin peptide exendin-4 directly impacts GLP-1 receptor signalling and trafficking
Maria Lucey, Tanyel Ashik, Amaara Marzook, Yifan Wang, Joëlle Goulding, Atsuro Oishi, View ORCID ProfileJohannes Broichhagen, David J Hodson, James Minnion, Yuval Elani, Ralf Jockers, Stephen J Briddon, Stephen R Bloom, Alejandra Tomas, View ORCID ProfileBen Jones
doi: https://doi.org/10.1101/2021.04.01.438030
Maria Lucey
1Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, W12 0NN, UK
Tanyel Ashik
1Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, W12 0NN, UK
Amaara Marzook
1Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, W12 0NN, UK
Yifan Wang
2Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, W12 0NN, UK
Joëlle Goulding
3Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK
4Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, UK
Atsuro Oishi
5Université de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France
6Department of Anatomy, Kyorin University Faculty of Medicine, Tokyo, Japan
Johannes Broichhagen
7Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Department of Chemical Biology, Berlin, Germany
David J Hodson
4Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, UK
8Institute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK
9Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
James Minnion
1Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, W12 0NN, UK
Yuval Elani
10Department of Chemical Engineering, Imperial College London, Exhibition Road, London,UK
Ralf Jockers
5Université de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France
Stephen J Briddon
3Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK
4Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, UK
Stephen R Bloom
1Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, W12 0NN, UK
Alejandra Tomas
2Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, W12 0NN, UK
Ben Jones
1Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, W12 0NN, UK
Posted April 01, 2021.
Acylation of the incretin peptide exendin-4 directly impacts GLP-1 receptor signalling and trafficking
Maria Lucey, Tanyel Ashik, Amaara Marzook, Yifan Wang, Joëlle Goulding, Atsuro Oishi, Johannes Broichhagen, David J Hodson, James Minnion, Yuval Elani, Ralf Jockers, Stephen J Briddon, Stephen R Bloom, Alejandra Tomas, Ben Jones
bioRxiv 2021.04.01.438030; doi: https://doi.org/10.1101/2021.04.01.438030
Acylation of the incretin peptide exendin-4 directly impacts GLP-1 receptor signalling and trafficking
Maria Lucey, Tanyel Ashik, Amaara Marzook, Yifan Wang, Joëlle Goulding, Atsuro Oishi, Johannes Broichhagen, David J Hodson, James Minnion, Yuval Elani, Ralf Jockers, Stephen J Briddon, Stephen R Bloom, Alejandra Tomas, Ben Jones
bioRxiv 2021.04.01.438030; doi: https://doi.org/10.1101/2021.04.01.438030
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