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A Comprehensive Phylogenetic and Bioinformatics Survey of Lectins in the Fungal kingdom

Annie Lebreton, View ORCID ProfileFrançois Bonnardel, Yu-Cheng Dai, View ORCID ProfileAnne Imberty, Francis M. Martin, View ORCID ProfileFrédérique Lisacek
doi: https://doi.org/10.1101/2021.04.01.438069
Annie Lebreton
1Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing, China
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François Bonnardel
2University of Grenoble-Alpes, CNRS, CERMAV, 38000 Grenoble, France
3Swiss Institute of Bioinformatics, CH-1227 Geneva, Switzerland
4Computer Science Department, UniGe, CH-1227 Geneva, Switzerland
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Yu-Cheng Dai
1Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing, China
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Anne Imberty
2University of Grenoble-Alpes, CNRS, CERMAV, 38000 Grenoble, France
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  • For correspondence: anne.imberty@cermav.cnrs.fr francis.martin@inrae.fr frederique.lisacek@sib.swiss
Francis M. Martin
1Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing, China
5Université de Lorraine, INRAE, UMR Interactions Arbres/Microorganismes (IAM), Laboratoire d’excellence ARBRE, Centre INRAE GrandEst-Nancy, Champenoux, France
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  • For correspondence: anne.imberty@cermav.cnrs.fr francis.martin@inrae.fr frederique.lisacek@sib.swiss
Frédérique Lisacek
3Swiss Institute of Bioinformatics, CH-1227 Geneva, Switzerland
4Computer Science Department, UniGe, CH-1227 Geneva, Switzerland
6Section of Biology, UniGe, CH-1205 Geneva, Switzerland
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  • For correspondence: anne.imberty@cermav.cnrs.fr francis.martin@inrae.fr frederique.lisacek@sib.swiss
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Abstract

Fungal lectins are a large family of glycan-binding proteins, with no enzymatic activity. They play fundamental biological roles in the interactions of fungi with their environment and are found in many different species throughout the fungal kingdom. In particular, their contribution to defence against feeders has been emphasized and extracellular lectins may be involved in the recognition of bacteria, fungal competitors and specific host plants. Their carbohydrate specificities and quaternary structures vary widely, but evidence for an evolutionary relationship within the different classes of lectins is provided by the high degree of amino acid sequence identity shared by the different fungal lectins. The UniLectin3D database contains 194 3D structures of fungal lectins, of which 129 are characterized with their carbohydrate ligand. UniLectin3D lectin classes from all origins were used to construct 107 lectin motifs in 26 folding configurations and to screen 1,223 species deposited in the genomic portal MycoCosm of the Joint Genome Institute. The resulting 33 485 protein sequences of putative lectins are organized in MycoLec, a publicly available and searchable database. The characterization of the lectin candidates in fungal genomes is based on systematic statistics regarding potential carbohydrate ligands, protein lengths, signal peptides, relative motif positions and amino acid compositions of fungal lectins. These results shed light on the evolution of the lectin gene families.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://www.unilectin.eu/mycolec/

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted April 03, 2021.
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A Comprehensive Phylogenetic and Bioinformatics Survey of Lectins in the Fungal kingdom
Annie Lebreton, François Bonnardel, Yu-Cheng Dai, Anne Imberty, Francis M. Martin, Frédérique Lisacek
bioRxiv 2021.04.01.438069; doi: https://doi.org/10.1101/2021.04.01.438069
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A Comprehensive Phylogenetic and Bioinformatics Survey of Lectins in the Fungal kingdom
Annie Lebreton, François Bonnardel, Yu-Cheng Dai, Anne Imberty, Francis M. Martin, Frédérique Lisacek
bioRxiv 2021.04.01.438069; doi: https://doi.org/10.1101/2021.04.01.438069

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