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HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1
View ORCID ProfileRachel J. Harding, View ORCID ProfileJustin C. Deme, View ORCID ProfileJohannes F. Hevler, View ORCID ProfileSem Tamara, Alexander Lemak, View ORCID ProfileJeffrey P. Cantle, View ORCID ProfileMagdalena M. Szewczyk, Xiaobing Zuo, Peter Loppnau, Alma Seitova, Ashley Hutchinson, Lixin Fan, View ORCID ProfileMatthieu Schapira, View ORCID ProfileJeffrey B. Carroll, View ORCID ProfileAlbert J. R. Heck, View ORCID ProfileSusan M. Lea, View ORCID ProfileCheryl H. Arrowsmith
doi: https://doi.org/10.1101/2021.04.02.438217
Rachel J. Harding
1Structural Genomics Consortium, University of Toronto, Ontario M5G 1L7, Canada
Justin C. Deme
2Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
3Central Oxford Structural Molecular Imaging Centre, University of Oxford, South Parks Road, Oxford, OX13RE
4Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
Johannes F. Hevler
5Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
6Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, The Netherlands
Sem Tamara
5Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
6Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, The Netherlands
Alexander Lemak
7Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada
Jeffrey P. Cantle
8Behavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, 98225, United States
Magdalena M. Szewczyk
1Structural Genomics Consortium, University of Toronto, Ontario M5G 1L7, Canada
Xiaobing Zuo
9X-ray Science Division, Argonne National Laboratory, Lemont, Illinois, 60439 USA
Peter Loppnau
1Structural Genomics Consortium, University of Toronto, Ontario M5G 1L7, Canada
Alma Seitova
1Structural Genomics Consortium, University of Toronto, Ontario M5G 1L7, Canada
Ashley Hutchinson
1Structural Genomics Consortium, University of Toronto, Ontario M5G 1L7, Canada
Lixin Fan
10Basic Science Program, Frederick National Laboratory for Cancer Research, SAXS Core of NCI, National Institutes of Health, Frederick, Maryland 21701
Matthieu Schapira
1Structural Genomics Consortium, University of Toronto, Ontario M5G 1L7, Canada
11Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Jeffrey B. Carroll
8Behavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, 98225, United States
Albert J. R. Heck
5Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
6Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, The Netherlands
Susan M. Lea
2Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
3Central Oxford Structural Molecular Imaging Centre, University of Oxford, South Parks Road, Oxford, OX13RE
4Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
Cheryl H. Arrowsmith
1Structural Genomics Consortium, University of Toronto, Ontario M5G 1L7, Canada
7Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada
Posted April 02, 2021.
HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1
Rachel J. Harding, Justin C. Deme, Johannes F. Hevler, Sem Tamara, Alexander Lemak, Jeffrey P. Cantle, Magdalena M. Szewczyk, Xiaobing Zuo, Peter Loppnau, Alma Seitova, Ashley Hutchinson, Lixin Fan, Matthieu Schapira, Jeffrey B. Carroll, Albert J. R. Heck, Susan M. Lea, Cheryl H. Arrowsmith
bioRxiv 2021.04.02.438217; doi: https://doi.org/10.1101/2021.04.02.438217
HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1
Rachel J. Harding, Justin C. Deme, Johannes F. Hevler, Sem Tamara, Alexander Lemak, Jeffrey P. Cantle, Magdalena M. Szewczyk, Xiaobing Zuo, Peter Loppnau, Alma Seitova, Ashley Hutchinson, Lixin Fan, Matthieu Schapira, Jeffrey B. Carroll, Albert J. R. Heck, Susan M. Lea, Cheryl H. Arrowsmith
bioRxiv 2021.04.02.438217; doi: https://doi.org/10.1101/2021.04.02.438217
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